Contribution of Genetic Background and Clinical Risk Factors to Low-Trauma Fractures in Human Immunodeficiency Virus (HIV)-Positive Persons: The Swiss HIV Cohort Study.

Détails

Ressource 1Télécharger: BIB_F88B7CFA1164.P001.pdf (177.27 [Ko])
Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_F88B7CFA1164
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Contribution of Genetic Background and Clinical Risk Factors to Low-Trauma Fractures in Human Immunodeficiency Virus (HIV)-Positive Persons: The Swiss HIV Cohort Study.
Périodique
Open Forum Infectious Diseases
Auteur(s)
Junier T., Rotger M., Biver E., Ledergerber B., Barceló C., Bartha I., Kovari H., Schmid P., Fux C., Bernasconi E., Brun Del Re C., Weber R., Fellay J., Tarr P.E.
ISSN
2328-8957 (Electronic)
ISSN-L
2328-8957
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
3
Numéro
2
Pages
ofw101
Langue
anglais
Résumé
Background.  The impact of human genetic background on low-trauma fracture (LTF) risk has not been evaluated in the context of human immunodeficiency virus (HIV) and clinical LTF risk factors. Methods.  In the general population, 6 common single-nucleotide polymorphisms (SNPs) associate with LTF through genome-wide association study. Using genome-wide SNP arrays and imputation, we genotyped these SNPs in HIV-positive, white Swiss HIV Cohort Study participants. We included 103 individuals with a first, physician-validated LTF and 206 controls matched on gender, whose duration of observation and whose antiretroviral therapy start dates were similar using incidence density sampling. Analyses of nongenetic LTF risk factors were based on 158 cases and 788 controls. Results.  A genetic risk score built from the 6 LTF-associated SNPs did not associate with LTF risk, in both models including and not including parental hip fracture history. The contribution of clinical LTF risk factors was limited in our dataset. Conclusions.  Genetic LTF markers with a modest effect size in the general population do not improve fracture prediction in persons with HIV, in whom clinical LTF risk factors are prevalent in both cases and controls.
Pubmed
Open Access
Oui
Création de la notice
24/07/2016 20:19
Dernière modification de la notice
09/05/2019 3:41
Données d'usage