Suicidal ideation in a European Huntington's disease population.
Details
Serval ID
serval:BIB_F884EDBBEFE3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Suicidal ideation in a European Huntington's disease population.
Journal
Journal of Affective Disorders
Working group(s)
REGISTRY investigators of the European Huntington's Disease Network
Contributor(s)
Bachoud-Lévi AC., Bentivoglio AR., Biunno I., Bonelli RM., Burgunder JM., Dunnett SB., Ferreira JJ., Handley OJ., Heiberg A., llmann TI., Landwehrmeyer GB., Levey J., Ramos-Arroyo MA., Nielsen JE., ProKoivisto S., Päivärinta M., Roos RA., Rojo Sebastián A., Tabrizi SJ., Vandenberghe W., Verellen- Dumoulin C., Zaremba J., Uhrova T., Wahlström J., Barth K., Correia-Guedes L., Finisterra AM., Garde MB., Bos R., Betz S., Callaghan J., Fullam R., Ecker D., Nielsen MG., Handley OJ., Hvalstedt C., Held C., Koppers K., Laurà M., Horta SM., Descals£££Asunción Martínez£££ AM. , Mestre T., Minster S., Monza D., Mütze L., Oehmen M., Townhill J., Orth M., Padieu H., Paterski L., Peppa N., Pro Koivisto S., Roedig V., Rialland A., Røren N., ?a?inková P. , Seliverstov Y., Cubillo PT., Walsem MR., Wright A., da Silva WV. , Witjes-Ané MN., Yudina E., Zielonka D., Zielonka E., Zinzi P., Bonelli RM., Herranhof B., Holl A., Kapfhammer HP., Koppitz M., Magnet M., Otti D., Painold A., Reisinger K., Scheibl M., Hecht K., Lilek S., Müller N., Schöggl H., Ullah J., Brugger F., Hepperger C., Hotter A., Seppi K., Wenning G., Buratti L., Hametner EM., Holas C., Hametner EM., Hussl A., Poewe W., Braunwarth EM., Sprenger F., Müller C., Lilek S., Sinadinosa D., Walleczek AM., Bonelli RM., Ladurner G., Staffen W., Flamez A., Morez V., de Raedt S., Boogaerts A., Vandenberghe W., van Reijen D., Klempíř£££Jiří£££ J. , Majerová V., Roth J., Hartikainen£££Päivi£££ P. , Hiivola H., Martikainen K., Tuuha K., Ignatius J., Kärppä M., Åman J., Mustonen A., Kajula O., Santala M., Allain P., Guérid MA., Gohier B., Olivier A., Prundean A., Scherer- Gagou C., Verny C., Bost M., Babiloni B., Debruxelles S., Duché C., Goizet C., Lafoucrière D., Jameau L., Spampinato U., De Bruycker C., Cabaret M., Carette AS., Defebvre L., Decorte E., Delval A., Delliaux M., Destee A., Dujardin K., Peter M., Plomhouse L., Sablonnière B., Simonin C., Defebvre L., Lemaire MH., Manouvrier S., Thibault-Tanchou S., Vuillaume I., Krystkowiak P., Duru C., Roussel M., Wannepain S., Berrissoul H., Bellonet M., Courtin F., Mantaux B., Fasquel V., Godefroy O., Azulay JP., Fluchère F., Delfini M., Eusebio A., Mundler L., Longato N., Rudolf G., Steinmetz G., Tranchant C., Wagner C., Zimmermann M., Marcel C., Calvas F., Pariente J., Démonet JF., Cheriet S., Kosinski CM., Milkereit E., Probst D., Reetz K., Sass C., Schiefer J., Schlangen C., Werner CJ., Gelderblom H., Priller J., Prüß H., Spruth EJ., Andrich J., Ellrichmann G., Hoffmann R., Kaminski B., Saft C., Stamm C., Lange H., Bosredon C., Maass A., Schmidt S., Storch A., Wolz M., Kohl Z., Winkler J., Capetian P., Lambeck J., Zucker B., Boelmans K., Ganos C., Goerendt I., Hidding U., Lewerenz J., Münchau A., Orth M., Schmalfeld J., Stubbe L., Zittel S., Diercks G., Dressler D., Gorzolla H., Schrader C., Tacik P., Heinicke W., Longinus B., Bürk K., Möller JC., Rissling I., Mühlau M., Peinemann A., Städtler M., Weindl A., Winkelmann J., Ziegler C., Bohlen S., Hölzner E., Lange H., Reilmann R., Sass C., Dose M., Leythaeuser G., Marquard R., Raab T., Schrenk C., Schuierer M., Barth K., Buck A., Connemann J., Ecker D., Eschenbach C., Held C., Landwehrmeyer B., Lezius F., Nepper S., Niess A., Orth M., Schwenk D., Süßmuth S., Trautmann S., Weydt P., Cormio C., Sciruicchio V., Serpino C., Tommaso M., Capellari S., Cortelli P., Gallassi R., Poda R., Rizzo G., Scaglione C., Bertini E., Ghelli E., Ginestroni A., Massaro F., Mechi C., Paganini M., Piacentini S., Pradella S., Romoli AM., Sorbi S., Abbruzzese G., di Poggio MB. , Di Maria E., Ferrandes G., Mandich P., Marchese R., Albanese A., Di Bella D., Di Donato S., Gellera C., Genitrini S., Mariotti C., Monza D., Nanetti L., Paridi D., Soliveri P., Tomasello C., De Michele G., Di Maio L., Salvatore E., Rinaldi C., Rossi F., Massarelli M., Roca A., Ammendola S., Russo CV., Squitieri F., Elifani F., Maglione V., Di Pardo A., Alberti S., Griguoli A., Amico E., Martino T., Petrollini M., Bentivoglio AR., Catalli C., Di Giacopo R., Fasano A., Frontali M., Guidubaldi A., Ialongo T., Jacopini G., Loria G., Piano C., Chiara P., Quaranta D., Romano S., Soleti F., Spadaro M., Zinzi P., Rinaldi C., Rossi F., Massarelli M., Roca A., Ammendola S., Russo CV., Squitieri F., Elifani F., Maglione V., Alberti S., Griguoli A., Amico E., Martino T., Petrollini M., Bentivoglio AR., Catalli C., Di Giacopo R., Fasano A., Frontali M., Guidubaldi A., Ialongo T., Jacopini G., Loria G., Piano C., Chiara P., Quaranta D., Romano S., Soleti F., Spadaro M., Zinzi P., van Hout MS. , van Vugt JP. , Weert A., Bolwijn J., Dekker M., Leenders K., Kremer HP., Bos R., Dumas EM., van den Bogaard SJ. , Roos RA., 't Hart EP. , van Duijn E., Økland E., Hauge E., Tyvoll H., Heiberg A., Walsem MR., Frich J., Aaserud O., Wehus R., Bjørgo K., Fannemel M., Gørvell P., Lorentzen E., Koivisto SP., Retterstøl L., Overland T., Stokke B., Sando B., Dziadkiewicz A., Nowak M., Robowski P., Sitek E., Slawek J., Soltan W., Szinwelski M., Blaszcyk M., Boczarska-Jedynak M., Ciach-Wysocka E., Gorzkowska A., Jasinska-Myga B., Opala G., Kłodowska-Duda G., Stompel D., Banaszkiewicz K., Boćwińska D., Szczudlik A., Rudzińska M., Wójcik M., Dec£££Małgorzata£££ M. , Krawczyk M., Jaremek KB., Szczygieł£££Elżbieta£££ E. , Stenwak A., ielewska AW., Bryl A., Ciesielska A., Klimberg A., Marcinkowski J., Sempołowicz J., Zielonka D., Samara H., Wiśniewski£££Bartłomiej£££ B. , Janik P., Gogol A., Kwiecinski H., Jamrozik Z., Kaminska A., Antczak J., Jachinska K., Rakowicz M., Richter P., Rola R., Ryglewicz D., Sienkiewicz-Jarosz H., Stępniak I., Witkowski G., Zdzienicka E., Zaremba J., Sułek A., Krysa W., Stępniak I., Zieora-Jakutowicz K., Júlio F., Januário C., Mestre T., Correia-Guedes L., Coelho M., Mendes T., Valadas A., Ferreira JJ., Timóteo£££Ângela£££ Â. , Costa C., Cavaco S., Damásio J., Loureiro R., Magalhães M., Andrade C., Gago M., Garrett C., Guerra£££Maria Rosália£££ MR. , Lima J., Massano£££João£££ J. , Meireles J., Herrera£££Carmen Durán£££ CD. , Garcia PM., Barrero F., Morales B., Cubo E., Mariscal N., Sánchez£££Jesús£££ J. , Alonso-Frech F., Perez MR., Fenollar£££María£££ M. , García£££Rocío García-Ramos£££ RG. , Quiroga PP., Rivera£££Susana Vázquez£££ SV. , Villanueva C., Alegre J., Bascuñana£££Mónica£££ M. , Caldentey JG., Ventura£££Marta Fatás£££ MF. , Ribas£££Guillermo García£££ GG. , Yébenes£££Justo Garcíade£££ JG. , López-Sendón Moreno JL. , Cubillo PT., García Ruíz PJ. , Martínez-Descals£££Asunción£££ A. , Artiga£££María José Saiz£££ MJ. , Sánchez V., Guerrero R., Bárcenas AH., Noguera Perea£££María Fuensanta£££ MF. , Fortuna L., Martirio£££María£££ M. , Torres A., Reinante G., Moreau LV., Barbera MA., Guia DB., Hernanz LC., Catena£££Judit López£££ JL. , Sebastián AR., Ferrer PQ., Carruesco GT., Bas J., Busquets£££Núria£££ N. , Calopa M., Elorza MD., Díez-AjaLópez£££Cristóbal£££ C. , Terol£££Santiago Durán-Sindreu£££ SD. , Robert MF., Ruíz£££Belén Garzón£££ BG. , Casado£££Ana González£££ AG. , Martínez IH., Viladrich CM., Càrdenas RP., Roca E., Llesoy JR., Idiago£££Jesús Miguel Ruiz£££ JM. , Vergara£££Mar Ruíz£££ MR. , García SS., Riballo AV., González£££Sonia González£££ SG. , Guisasola LM., Salvador C., San Martín ES. , González£££Mónica£££ M. , Gorospe£££Aranzazú£££ A. , Legarda I., Arques PN., Torres Rodríguez£££María Jos飣£ MJ. , Vives B., Gaston I., Ramos-Arroyo MA., Martinez-Jaurrieta MD., Manuel J., Moreno G., Peña£££José Chacón£££ JC. , Avarvarei LD., Bastida£££Antonio Martín£££ AM. , Recio£££Maria Fernández£££ MF. , Vergé LR., Sánchez£££Violeta Sánchez£££ VS. , Carrillo£££Fátima£££ F. , Cáceres£££María Teresa£££ MT. , Mir P., Suarez£££María José Lama£££ MJ. , Bosca M., Burguera JA., Garcia AC., Brugada£££Francisco Casterᣣ£ FC. , Martínez LM., Val£££Javier Lópezdel£££ JL. , Loutfi G., Olofsson C., Stattin EL., Westman L., Wikström B., lhagen SE., Paucar M., Svenningsson P., Reza- Soltani TW. , Höglund A., Sandström B., Wahlström J., Høsterey-Ugander U., Fredlund G., Constantinescu R., Neleborn-Lingefjärd L., Tedr- off J., Esmaeilzadeh M., Winnberg E., Pålhagen S., Svennigsson P., Paucar M., Riza-Soltani TW., Sundblom J., Johansson A., Wiklund L., Ekwall C., Göller ML., Petersén A., Reimer J., Widner H., Burgunder JM., Stebler Y., Kaelin A., Romero I., Schüpbach M., Weber S., Miedzybrodzka Z., Rae D., Downie L., Simpson S., Summers F., Ure A., Jack R., Matheson K., Akhtar S., Crooks J., Curtis A., Souza J., Rickards H., Wright J., Hayward B., Sieradzan K., Wright A., Barker RA., O'Keefe D., Di Pietro A., Fisher K., Hill S., Mason S., Swain R., Valle N., Guzman , Bisson J., Busse M., Butcher C., Callaghan J., Clenaghan C., Dunnett S., Fullam R., Handley O., Hunt S., Hughes A., Johnstone C., Jones L., Jones U., Khalil H., Minster S., Owen M., Price K., Rose LE., Townhill J., Rosser A., Porteous M., Edwards M., Ho C., McGill M., Pearson P., Brockie P., Foster J., Johns N., McKenzie S., Rothery J., Thomas G., Yates S., Miller J., Ritchie S., Burrows L., Fletcher A., Harding A., Laver F., Silva M., Thomson A., Rowett L., Gallantrae D., Longthorpe M., Markova I., Raman A., Hamer S., Wild S., Yarduiman P., Chu C., Kraus A., Wild S., Yardumian P., Musgrave H., Rowett L., Toscano J., Jamieson S., Hobson E., Clayton C., Dipple H., Middleton J., Freire-Patino D., Andrews T., Dougherty A., Kavalier F., Golding C., Laing H., Lashwood A., Robertson D., Ruddy D., Whaite A., Santhouse A., Patton M., Peterson M., Rose S., Andrews T., Bruno S., Chu E., Doherty K., Golding C., Haider S., Hensman D., Lahiri N., Lewis M., Novak M., Patel A., Robertson N., Rosser E., Tabrizi S., Taylor R., Warner T., Wild E., Craufurd D., Fullam R., Howard L., Sollom A., Snowden J., Thompson J., Callaghan J., Jones M., Murphy H., Trender-Gerhard I., Rogers D., Bek J., Oughton E., Johnson L., Hare M., Arran N., Verstraelen N., Partington-Jones L., Huson S., Stopford C., Westmoreland L., Davidson J., Morgan K., Savage L., Singh B., Komati S., Nemeth AH., Armstrong R., Valentine R., Siuda G., Harrison D., Hughes M., Parkinson A., Soltysiak B., Burn J., Coleman C., Bandmann O., Bradbury A., Gill P., Fairtlough H., Fillingham K., Foustanos I., Kazoka M., O'Donovan K., Peppa N., Taylor C., Tidswell K., Quarrell O.
ISSN
1573-2517 (Electronic)
ISSN-L
0165-0327
Publication state
Published
Issued date
2013
Volume
151
Number
1
Pages
248-258
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish. JF Demonet fait partie de REGISTRY investigators of the European Huntington's Disease Network.
Abstract
BACKGROUND: Previous studies indicate increased prevalences of suicidal ideation, suicide attempts, and completed suicide in Huntington's disease (HD) compared with the general population. This study investigates correlates and predictors of suicidal ideation in HD.
METHODS: The study cohort consisted of 2106 HD mutation carriers, all participating in the REGISTRY study of the European Huntington's Disease Network. Of the 1937 participants without suicidal ideation at baseline, 945 had one or more follow-up measurements. Participants were assessed for suicidal ideation by the behavioural subscale of the Unified Huntington's Disease Rating Scale (UHDRS). Correlates of suicidal ideation were analyzed using logistic regression analysis and predictors were analyzed using Cox regression analysis.
RESULTS: At baseline, 169 (8.0%) mutation carriers endorsed suicidal ideation. Disease duration (odds ratio [OR]=0.96; 95% confidence interval [CI]: 0.9-1.0), anxiety (OR=2.14; 95%CI: 1.4-3.3), aggression (OR=2.41; 95%CI: 1.5-3.8), a previous suicide attempt (OR=3.95; 95%CI: 2.4-6.6), and a depressed mood (OR=13.71; 95%CI: 6.7-28.0) were independently correlated to suicidal ideation at baseline. The 4-year cumulative incidence of suicidal ideation was 9.9%. Longitudinally, the presence of a depressed mood (hazard ratio [HR]=2.05; 95%CI: 1.1-4.0) and use of benzodiazepines (HR=2.44; 95%CI: 1.2-5.0) at baseline were independent predictors of incident suicidal ideation, whereas a previous suicide attempt was not predictive.
LIMITATIONS: As suicidal ideation was assessed by only one item, and participants were a selection of all HD mutation carriers, the prevalence of suicidal ideation was likely underestimated.
CONCLUSIONS: Suicidal ideation in HD frequently occurs. Assessment of suicidal ideation is a priority in mutation carriers with a depressed mood and in those using benzodiazepines.
METHODS: The study cohort consisted of 2106 HD mutation carriers, all participating in the REGISTRY study of the European Huntington's Disease Network. Of the 1937 participants without suicidal ideation at baseline, 945 had one or more follow-up measurements. Participants were assessed for suicidal ideation by the behavioural subscale of the Unified Huntington's Disease Rating Scale (UHDRS). Correlates of suicidal ideation were analyzed using logistic regression analysis and predictors were analyzed using Cox regression analysis.
RESULTS: At baseline, 169 (8.0%) mutation carriers endorsed suicidal ideation. Disease duration (odds ratio [OR]=0.96; 95% confidence interval [CI]: 0.9-1.0), anxiety (OR=2.14; 95%CI: 1.4-3.3), aggression (OR=2.41; 95%CI: 1.5-3.8), a previous suicide attempt (OR=3.95; 95%CI: 2.4-6.6), and a depressed mood (OR=13.71; 95%CI: 6.7-28.0) were independently correlated to suicidal ideation at baseline. The 4-year cumulative incidence of suicidal ideation was 9.9%. Longitudinally, the presence of a depressed mood (hazard ratio [HR]=2.05; 95%CI: 1.1-4.0) and use of benzodiazepines (HR=2.44; 95%CI: 1.2-5.0) at baseline were independent predictors of incident suicidal ideation, whereas a previous suicide attempt was not predictive.
LIMITATIONS: As suicidal ideation was assessed by only one item, and participants were a selection of all HD mutation carriers, the prevalence of suicidal ideation was likely underestimated.
CONCLUSIONS: Suicidal ideation in HD frequently occurs. Assessment of suicidal ideation is a priority in mutation carriers with a depressed mood and in those using benzodiazepines.
Pubmed
Web of science
Open Access
Yes
Create date
17/01/2014 16:12
Last modification date
20/08/2019 17:24
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