Influence of HLA-C expression level on HIV control.

Détails

Ressource 1Télécharger: BIB_F83E60D4E8F2.P001.pdf (766.98 [Ko])
Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_F83E60D4E8F2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Influence of HLA-C expression level on HIV control.
Périodique
Science
Auteur(s)
Apps R., Qi Y., Carlson J.M., Chen H., Gao X., Thomas R., Yuki Y., Del Prete G.Q., Goulder P., Brumme Z.L., Brumme C.J., John M., Mallal S., Nelson G., Bosch R., Heckerman D., Stein J.L., Soderberg K.A., Moody M.A., Denny T.N., Zeng X., Fang J., Moffett A., Lifson J.D., Goedert J.J., Buchbinder S., Kirk G.D., Fellay J., McLaren P., Deeks S.G., Pereyra F., Walker B., Michael N.L., Weintrob A., Wolinsky S., Liao W., Carrington M.
ISSN
1095-9203 (Electronic)
ISSN-L
0036-8075
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
340
Numéro
6128
Pages
87-91
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov'tPublication Status: ppublish. PDF type: report
Résumé
A variant upstream of human leukocyte antigen C (HLA-C) shows the most significant genome-wide effect on HIV control in European Americans and is also associated with the level of HLA-C expression. We characterized the differential cell surface expression levels of all common HLA-C allotypes and tested directly for effects of HLA-C expression on outcomes of HIV infection in 5243 individuals. Increasing HLA-C expression was associated with protection against multiple outcomes independently of individual HLA allelic effects in both African and European Americans, regardless of their distinct HLA-C frequencies and linkage relationships with HLA-B and HLA-A. Higher HLA-C expression was correlated with increased likelihood of cytotoxic T lymphocyte responses and frequency of viral escape mutation. In contrast, high HLA-C expression had a deleterious effect in Crohn's disease, suggesting a broader influence of HLA expression levels in human disease.
Mots-clé
African Americans/genetics, Alleles, Amino Acid Sequence, Anti-Retroviral Agents/therapeutic use, Crohn Disease/genetics, Crohn Disease/immunology, Gene Expression Regulation, HIV/genetics, HIV/immunology, HIV Infections/drug therapy, HIV Infections/genetics, HLA-C Antigens/genetics, Humans, Immunodominant Epitopes/genetics, Molecular Sequence Data, Mutation, Peptide Fragments/immunology, Polymorphism, Single Nucleotide, T-Lymphocytes, Cytotoxic/immunology, Viral Load/genetics
Pubmed
Web of science
Création de la notice
03/05/2013 20:36
Dernière modification de la notice
03/03/2018 22:51
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