A synthetic malaria vaccine elicits a potent CD8(+) and CD4(+) T lymphocyte immune response in humans. Implications for vaccination strategies

Détails

ID Serval
serval:BIB_F82E98AA87F9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A synthetic malaria vaccine elicits a potent CD8(+) and CD4(+) T lymphocyte immune response in humans. Implications for vaccination strategies
Périodique
European Journal of Immunology
Auteur(s)
Lopez  J. A., Weilenman  C., Audran  R., Roggero  M. A., Bonelo  A., Tiercy  J. M., Spertini  F., Corradin  G.
ISSN
0014-2980 (Print)
Statut éditorial
Publié
Date de publication
07/2001
Volume
31
Numéro
7
Pages
1989-98
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul
Résumé
We report the first synthetic peptide vaccine eliciting strong CD8(+) and CD4(+) T lymphocyte responses in humans. The vaccine, representing the C-terminal region of the circumsporozoite protein of Plasmodium falciparum (amino acids 282-383) was well tolerated and strong sporozoite-specific antibodies were elicited. In addition, robust lymphocyte proliferation responses were equally elicited with concomitant in vitro production of IFN-gamma, crucial in the elimination of the parasite. Most importantly, we also observed the development of CD8(+) T lymphocyte responses decisive in the immunity to malaria. The latter finding opens new, possibly safer, avenues for vaccination strategies when a CD8(+) T cell response is needed.
Mots-clé
Adult Animals Antibodies, Protozoan/biosynthesis Antibody Specificity Antigens, Protozoan/immunology CD4-Positive T-Lymphocytes/*immunology CD8-Positive T-Lymphocytes/*immunology Cells, Cultured Female HLA-A Antigens/immunology Humans Immunologic Memory Interferon Type II/biosynthesis Lymphocyte Activation Malaria Vaccines/adverse effects/*pharmacology Malaria, Falciparum/immunology/*therapy Male Peptide Fragments/*immunology Peptides/immunology Plasmodium falciparum/*immunology Protozoan Proteins/*immunology Th1 Cells/immunology Vaccines, Synthetic/adverse effects/pharmacology
Pubmed
Web of science
Création de la notice
24/01/2008 15:55
Dernière modification de la notice
03/03/2018 22:51
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