Article: article from journal or magazin.
recA-independent mutagenicity induced by chloroethylene oxide in E. coli.
The mechanism of mutagenicity of chloroethylene oxide (CEO), an ultimate carcinogenic metabolite of vinyl chloride, was investigated in 3 Escherichia coli strains (E. coli "multitest"). In this system, the mutagenicity of CEO was found to be mainly SOS-independent. CEO did not induce recombinational events at a detection level of about 10(-2) recombinants/survivor. Our results indicate that CEO- (or vinyl chloride-) induced bacterial mutagenesis arises mainly from miscoding DNA adducts.
Escherichia coli/drug effects, Escherichia coli/genetics, Ethylene Oxide/analogs & derivatives, Ethylene Oxide/pharmacology, Kinetics, Mutagenicity Tests, Mutagens, Mutation, Rec A Recombinases/genetics, Species Specificity
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