recA-independent mutagenicity induced by chloroethylene oxide in E. coli.
Details
Serval ID
serval:BIB_F82935707785
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
recA-independent mutagenicity induced by chloroethylene oxide in E. coli.
Journal
Mutation Research
ISSN
0027-5107 (Print)
ISSN-L
0027-5107
Publication state
Published
Issued date
1985
Volume
152
Number
2-3
Pages
157-159
Language
english
Abstract
The mechanism of mutagenicity of chloroethylene oxide (CEO), an ultimate carcinogenic metabolite of vinyl chloride, was investigated in 3 Escherichia coli strains (E. coli "multitest"). In this system, the mutagenicity of CEO was found to be mainly SOS-independent. CEO did not induce recombinational events at a detection level of about 10(-2) recombinants/survivor. Our results indicate that CEO- (or vinyl chloride-) induced bacterial mutagenesis arises mainly from miscoding DNA adducts.
Keywords
Escherichia coli/drug effects, Escherichia coli/genetics, Ethylene Oxide/analogs & derivatives, Ethylene Oxide/pharmacology, Kinetics, Mutagenicity Tests, Mutagens, Mutation, Rec A Recombinases/genetics, Species Specificity
Pubmed
Web of science
Create date
01/04/2011 11:18
Last modification date
20/08/2019 17:24
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