recA-independent mutagenicity induced by chloroethylene oxide in E. coli.

Détails

ID Serval
serval:BIB_F82935707785
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
recA-independent mutagenicity induced by chloroethylene oxide in E. coli.
Périodique
Mutation Research
Auteur(s)
Barbin A., Tenenbaum L., Toman Z., Radman M., Bartsch H.
ISSN
0027-5107 (Print)
ISSN-L
0027-5107
Statut éditorial
Publié
Date de publication
1985
Volume
152
Numéro
2-3
Pages
157-159
Langue
anglais
Résumé
The mechanism of mutagenicity of chloroethylene oxide (CEO), an ultimate carcinogenic metabolite of vinyl chloride, was investigated in 3 Escherichia coli strains (E. coli "multitest"). In this system, the mutagenicity of CEO was found to be mainly SOS-independent. CEO did not induce recombinational events at a detection level of about 10(-2) recombinants/survivor. Our results indicate that CEO- (or vinyl chloride-) induced bacterial mutagenesis arises mainly from miscoding DNA adducts.
Mots-clé
Escherichia coli/drug effects, Escherichia coli/genetics, Ethylene Oxide/analogs & derivatives, Ethylene Oxide/pharmacology, Kinetics, Mutagenicity Tests, Mutagens, Mutation, Rec A Recombinases/genetics, Species Specificity
Pubmed
Web of science
Création de la notice
01/04/2011 11:18
Dernière modification de la notice
03/03/2018 22:51
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