How stable is the risk curve between alcohol and all-cause mortality and what factors influence the shape? A precision-weighted hierarchical meta-analysis

Détails

ID Serval
serval:BIB_F81ED13DF820
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
How stable is the risk curve between alcohol and all-cause mortality and what factors influence the shape? A precision-weighted hierarchical meta-analysis
Périodique
European Journal of Epidemiology
Auteur(s)
Gmel  G., Gutjahr  E., Rehm  J.
ISSN
0393-2990 (Print)
Statut éditorial
Publié
Date de publication
2003
Volume
18
Numéro
7
Pages
631-42
Notes
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Résumé
OBJECTIVE: To determine the influence of six determining variables on the shape of the risk curve between alcohol and all-cause mortality. METHODS: DATA: Based on a systematic search with clear inclusion criteria, all articles on alcohol and all-cause mortality until 2000 were included. STATISTICAL METHODS: Precision-weighted pooling of relative risks (RRs); precision-weighted hierarchical analysis. VARIABLES: For pooling: RRs for different categories of average volume of drinking, lifetime abstainers and ex-drinkers. For hierarchical analysis: on first level: consumption in grams of pure alcohol per day; on second level: length of follow-up time in months; per capita consumption; average age, proportion of abstainers, average volume of drinking, and variability of average volume of drinking at baseline. OUTCOMES MEASURES: RR of former and current drinkers for all-cause mortality compared to abstainers. RESULTS: The main hypotheses could be confirmed for males: Ex-drinkers had a higher mortality risk than lifetime abstainers; the higher and the more diverse the average volume of alcohol consumption, the wider the dip of the curve; the older the persons at baseline, the more pronounced the protective effect; and the longer the follow-up time, the less pronounced the protective effect. Except for average volume of drinking effects for females went in the same direction but with one exception did not reach significance. CONCLUSIONS: There are systematic influences on the shape of the risk curve between alcohol and all-cause mortality. The overall beneficial effect of light to moderate drinking remained under all scenarios, indicating a high validity of the overall shape despite the heterogeneity between studies.
Mots-clé
Age Distribution Alcohol Drinking/*adverse effects/*mortality *Cause of Death Cohort Effect Effect Modifiers (Epidemiology) Epidemiologic Research Design Female Follow-Up Studies Humans Male Risk Risk Assessment Risk Factors Sex Distribution Sex Factors Time Factors
Pubmed
Web of science
Création de la notice
25/01/2008 18:15
Dernière modification de la notice
03/03/2018 22:51
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