Diabetic neuropathy is a more important determinant of baroreflex sensitivity than carotid elasticity in type 2 diabetes.

Détails

ID Serval
serval:BIB_F7972C76A3E5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Diabetic neuropathy is a more important determinant of baroreflex sensitivity than carotid elasticity in type 2 diabetes.
Périodique
Hypertension
Auteur(s)
Ruiz J., Monbaron D., Parati G., Perret S., Haesler E., Danzeisen C., Hayoz D.
ISSN
1524-4563[electronic]
Statut éditorial
Publié
Date de publication
2005
Volume
46
Numéro
1
Pages
162-7
Langue
anglais
Notes
Publication types: Journal Article - Publication Status: ppublish
Résumé
The object of this study was to evaluate the contribution of carotid distensibilty on baroreflex sensitivity in patients with type 2 diabetes mellitus with at least 2 additional cardiovascular risk factors. Carotid distensibility was measured bilaterally at the common carotid artery in 79 consecutive diabetic patients and 60 matched subjects without diabetes. Spontaneous baroreflex sensitivity assessment was obtained using time and frequency methods. Baroreflex sensitivity was lower in diabetic subjects as compared with nondiabetic control subjects (5.25+/-2.80 ms/mm Hg versus 7.55+/-3.79 ms/mm Hg; P<0.01, respectively). Contrary to nondiabetic subjects, diabetic subjects showed no significant correlation between carotid distensibility and baroreflex sensitivity (r2=0.08, P=0.04 and r2=0.04, P=0.13, respectively). In diabetic subjects, baroreflex sensitivity was significantly lower in subjects with peripheral neuropathy than in those with preserved vibration sensation (4.1+/-0.5 versus 6.1+/-0.4 ms/mm Hg, respectively; P=0.005). Age in nondiabetic subjects, diabetes duration, systolic blood pressure, peripheral or sensitive neuropathy, and carotid distensibility were introduced in a stepwise multivariate analysis to identify the determinants of baroreflex sensitivity. In diabetic patients, neuropathy is a more sensitive determinant of baroreflex sensitivity than the reduced carotid distensibility (stepwise analysis; F ratio=5.1, P=0.028 versus F ratio=1.9, P=0.16, respectively). In diabetic subjects with 2 additional cardiovascular risk factors, spontaneous baroreflex sensitivity is not related to carotid distensibility. Diabetic subjects represent a particular population within the spectrum of cardiovascular risk situations because of the marked neuropathy associated with their metabolic disorder. Therefore, neuropathy is a more significant determinant of baroreflex sensitivity than carotid artery elasticity in patients with type 2 diabetes.
Mots-clé
Adult, Aged, Aging, Atherosclerosis, Autonomic Nervous System, Baroreflex, Carotid Arteries, Case-Control Studies, Diabetes Mellitus, Type 2, Diabetic Neuropathies, Elasticity, Female, Humans, Male, Middle Aged, Multivariate Analysis
Pubmed
Web of science
Open Access
Oui
Création de la notice
29/01/2008 9:56
Dernière modification de la notice
09/05/2019 3:39
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