Individual measurements of angiotensin II concentrations in aqueous humor of the eye
Details
Serval ID
serval:BIB_F78DE973BF65
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Individual measurements of angiotensin II concentrations in aqueous humor of the eye
Journal
European Journal of Ophthalmology
ISSN
1120-6721 (Print)
Publication state
Published
Issued date
12/1994
Volume
4
Number
4
Pages
228-33
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Oct-Dec
Research Support, Non-U.S. Gov't --- Old month value: Oct-Dec
Abstract
The presence of constituents of the renin-angiotensin system (RAS) in ocular tissues and fluids suggests this system is involved in ocular physiology. Angiotensin II (AngII) is the main biological effector of the system, so we measured AngII in plasma and in aqueous humor of the anterior ocular chamber of patients undergoing cataract extraction. Untreated normotensive patients were compared with arterial hypertensive patients taking either diuretics which stimulate the RAS or angiotensin converting enzyme (ACE) inhibitors which reduce the production of AngII. Plasma levels of AngII were higher in patients on diuretics (5.46 +/- 1.04 fmol/ml; mean +/- SEM) than in untreated cataract patients (2.28 +/- 0.32 fmol/ml, p < 0.02), and were very low with ACE inhibitors (0.51 +/- 0.18 fmol/ml). In aqueous humor, AngII was measurable in 7 of 11 patients on diuretics (median 1.1 fmol/ml), and in 6 of 16 normotensive patients (median < 0.55 fmol/ml), but not in aqueous humor of 4 patients receiving enalapril or captopril. These results demonstrate the presence of AngII in the eye but do not exclude either its sequestration in the eye or local production. The possibility of individual measurements of intraocular AngII will permit more precise determination of its role in future studies.
Keywords
Aged
Aged, 80 and over
Angiotensin II/*analysis
Aqueous Humor/*chemistry
Cataract/blood/complications
Cataract Extraction
Chromatography, High Pressure Liquid
Diuretics/therapeutic use
Enalapril/therapeutic use
Female
Humans
Hypertension/blood/complications/drug therapy
Male
Middle Aged
Renin-Angiotensin System/physiology
Pubmed
Create date
05/03/2008 17:40
Last modification date
20/08/2019 17:23