Meta-analysis and imputation refines the association of 15q25 with smoking quantity.

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Etat: Public
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ID Serval
serval:BIB_F756B77E9388
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Meta-analysis and imputation refines the association of 15q25 with smoking quantity.
Périodique
Nature Genetics
Auteur(s)
Liu J.Z., Tozzi F., Waterworth D.M., Pillai S.G., Muglia P., Middleton L., Berrettini W., Knouff C.W., Yuan X., Waeber G., Vollenweider P., Preisig M., Wareham N.J., Zhao J.H., Loos R.J., Barroso I., Khaw K.T., Grundy S., Barter P., Mahley R., Kesaniemi A., McPherson R., Vincent J.B., Strauss J., Kennedy J.L., Farmer A., McGuffin P., Day R., Matthews K., Bakke P., Gulsvik A., Lucae S., Ising M., Brueckl T., Horstmann S., Wichmann H.E., Rawal R., Dahmen N., Lamina C., Polasek O., Zgaga L., Huffman J., Campbell S., Kooner J., Chambers J.C., Burnett M.S., Devaney J.M., Pichard A.D., Kent K.M., Satler L., Lindsay J.M., Waksman R., Epstein S., Wilson J.F., Wild S.H., Campbell H., Vitart V., Reilly M.P., Li M., Qu L., Wilensky R., Matthai W., Hakonarson H.H., Rader D.J., Franke A., Wittig M., Schäfer A., Uda M., Terracciano A., Xiao X., Busonero F., Scheet P., Schlessinger D., St Clair D., Rujescu D., Abecasis G.R., Grabe H.J., Teumer A., Völzke H., Petersmann A., John U., Rudan I., Hayward C., Wright A.F., Kolcic I., Wright B.J., Thompson J.R., Balmforth A.J., Hall A.S., Samani N.J., Anderson C.A., Ahmad T., Mathew C.G., Parkes M., Satsangi J., Caulfield M., Munroe P.B., Farrall M., Dominiczak A., Worthington J., Thomson W., Eyre S., Barton A., Mooser V., Francks C., Marchini J.
Collaborateur(s)
Wellcome Trust Case Control Consortium
ISSN
1546-1718 ([electronic])
1061-4036 ([linking])
Statut éditorial
Publié
Date de publication
2010
Peer-reviewed
Oui
Volume
42
Numéro
5
Pages
436-440
Langue
anglais
Résumé
Smoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits. Our final data set included 41,150 individuals drawn from 20 disease, population and control cohorts. Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 x 10(-19)) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic acetylcholine receptor subunits. We used data from the 1000 Genomes project to investigate the region using imputation, which allowed for analysis of virtually all common SNPs in the region and offered a fivefold increase in marker density over HapMap2 (ref. 2) as an imputation reference panel. Our fine-mapping approach identified a SNP showing the highest significance, rs55853698, located within the promoter region of CHRNA5. Conditional analysis also identified a secondary locus (rs6495308) in CHRNA3.
Mots-clé
Genome-Wide Association, Nicotine Dependence, Lung-Cancer, Susceptibility Locus, Risk-Factors, Disease, Genes, SNPS, Colaus Study
Pubmed
Web of science
Création de la notice
18/05/2010 15:13
Dernière modification de la notice
20/08/2019 17:23
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