Article: article from journal or magazin.
High-field dissolution dynamic nuclear polarization of [1-(13)C]pyruvic acid.
Physical Chemistry Chemical Physics : Pccp
Publication types: Journal ArticlePublication Status: ppublish
[1-(13)C]pyruvate is the most widely used hyperpolarized metabolic magnetic resonance imaging agent. Using a custom-built 7.0 T polarizer operating at 1.0 K and trityl radical-doped [1-(13)C]pyruvic acid, unextrapolated solution-state (13)C polarization greater than 60% was measured after dissolution and rapid transfer to a spectrometer magnet, demonstrating the signal enhancement attainable using optimized hardware. Slower rates of polarization under these conditions can be largely overcome with higher radical concentrations.
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