An integrated ontology resource to explore and study host-virus relationships.

Détails

Ressource 1Télécharger: BIB_F68E3C9906A9.P001.pdf (1175.67 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_F68E3C9906A9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
An integrated ontology resource to explore and study host-virus relationships.
Périodique
PLoS One
Auteur(s)
Masson P., Hulo C., de Castro E., Foulger R., Poux S., Bridge A., Lomax J., Bougueleret L., Xenarios I., Le Mercier P.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
9
Numéro
9
Pages
e108075
Langue
anglais
Résumé
Our growing knowledge of viruses reveals how these pathogens manage to evade innate host defenses. A global scheme emerges in which many viruses usurp key cellular defense mechanisms and often inhibit the same components of antiviral signaling. To accurately describe these processes, we have generated a comprehensive dictionary for eukaryotic host-virus interactions. This controlled vocabulary has been detailed in 57 ViralZone resource web pages which contain a global description of all molecular processes. In order to annotate viral gene products with this vocabulary, an ontology has been built in a hierarchy of UniProt Knowledgebase (UniProtKB) keyword terms and corresponding Gene Ontology (GO) terms have been developed in parallel. The results are 65 UniProtKB keywords related to 57 GO terms, which have been used in 14,390 manual annotations; 908,723 automatic annotations and propagated to an estimation of 922,941 GO annotations. ViralZone pages, UniProtKB keywords and GO terms provide complementary tools to users, and the three resources have been linked to each other through host-virus vocabulary.
Pubmed
Web of science
Open Access
Oui
Création de la notice
27/02/2015 17:45
Dernière modification de la notice
16/09/2019 5:26
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