Plasminogen activator inhibitor 1 and plasminogen activator inhibitor 2 in various disease states.

Details

Serval ID
serval:BIB_F6764A1D982B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Plasminogen activator inhibitor 1 and plasminogen activator inhibitor 2 in various disease states.
Journal
Thrombosis and Haemostasis
Author(s)
Kruithof E.K., Gudinchet A., Bachmann F.
ISSN
0340-6245
Publication state
Published
Issued date
1988
Peer-reviewed
Oui
Volume
59
Number
1
Pages
7-12
Language
english
Abstract
The association of increased PA-inhibitor (PAI) activity and of PAI-1 and PAI-2 antigen levels with different pathological conditions was studied in a collective of over 300 patients. PAI-1 and PAI-2 levels were measured by specific radioimmunoassays. A good correlation was observed of PAI activity with PAI-1 antigen (r = 0.718; p less than 0.0001) but not with PAI-2 (r = 0.070; n.s.). Both in the controls and in the patients, PAI activity and PAI-1 antigen showed an extremely large range of values. PAI activity ranged from 0.5 to 68 U/ml and PAI-1 antigen from 6 to 600 ng/ml. Increased PAI activity and PAI-1 antigen was observed in patients with malignant tumors, cardiovascular or thromboembolic disease, in the postoperative phase, with hepatic insufficiency, after trauma and after extracorporeal circulation. The large spectrum of disease states with increased PAI activity and PAI-1 antigen reinforces previous suggestions that PAI-1 is an acute phase reactant. After extracorporeal circulation, PAI activity and PAI-1 concentrations strongly increased within one hour, remained elevated for at least one week and returned to preoperation values within 7 days. PAI-2 values ranged from below detection limit (15 ng/ml), observed in half of the plasmas, to 485 ng/ml in a pregnant woman. High values of PAI-2 were only observed in pregnancy.
Keywords
Glycoproteins, Humans, Plasminogen Activators, Plasminogen Inactivators, Tissue Plasminogen Activator, Urokinase-Type Plasminogen Activator
Pubmed
Web of science
Create date
06/04/2009 13:00
Last modification date
20/08/2019 16:22
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