Alarm pheromone and kairomone detection via bitter taste receptors in the mouse Grueneberg ganglion.

Détails

Ressource 1Télécharger: 1-s2.0-S2211124717315991-main.pdf (6590.05 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_F64AEA348D4B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Alarm pheromone and kairomone detection via bitter taste receptors in the mouse Grueneberg ganglion.
Périodique
BMC biology
Auteur(s)
Moine F., Brechbühl J., Nenniger Tosato M., Beaumann M., Broillet M.C.
ISSN
1741-7007 (Electronic)
ISSN-L
1741-7007
Statut éditorial
Publié
Date de publication
18/01/2018
Peer-reviewed
Oui
Volume
16
Numéro
1
Pages
12
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
The mouse Grueneberg ganglion (GG) is an olfactory subsystem specialized in the detection of volatile heterocyclic compounds signalling danger. The signalling pathways transducing the danger signals are only beginning to be characterized.
Screening chemical libraries for compounds structurally resembling the already-identified GG ligands, we found a new category of chemicals previously identified as bitter tastants that initiated fear-related behaviours in mice depending on their volatility and evoked neuronal responses in mouse GG neurons. Screening for the expression of signalling receptors of these compounds in the mouse GG yielded transcripts of the taste receptors Tas2r115, Tas2r131, Tas2r143 and their associated G protein α-gustducin (Gnat3). We were further able to confirm their expression at the protein level. Challenging these three G protein-coupled receptors in a heterologous system with the known GG ligands, we identified TAS2R143 as a chemical danger receptor transducing both alarm pheromone and predator-derived kairomone signals.
These results demonstrate that similar molecular elements might be used by the GG and by the taste system to detect chemical danger signals present in the environment.
Mots-clé
Animals, Cats, Cell Line, Female, Ganglia, Autonomic/chemistry, Ganglia, Autonomic/metabolism, HEK293 Cells, Humans, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Pheromones/administration & dosage, Smell/drug effects, Smell/physiology, Taste/drug effects, Taste/physiology, Taste Buds/chemistry, Taste Buds/drug effects, Taste Buds/metabolism, Alarm pheromone, Danger detection, Grueneberg ganglion, Olfaction, Predator scents, TAS2Rs
Pubmed
Web of science
Open Access
Oui
Création de la notice
27/01/2018 13:11
Dernière modification de la notice
20/08/2019 16:22
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