Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Dépersonnalisation. Données actuelles.
Canadian Journal of Psychiatry
DA - 20050405 IS - 0706-7437 LA - fre PT - Journal Article PT - Review RN - 0 (Antidepressive Agents, Second-Generation) RN - 0 (Serotonin Uptake Inhibitors) RN - 50-67-9 (Serotonin) SB - IM Institution : Departement Universitaire de Psychiatrie Adulte, Hopital de Cery, Prilly-Lausanne. Yasser.Khazaal@hospvd.ch Notes sur le titre : Titre traduit: Depersonalization--current data Mention de responsabiblité : Khazaal,Yasser;Zimmermann,Gregoire;Zullino,Daniele Fabio SAPHIRID:48156 --- Old url value: http://ww1.cpa-apc.org:8080/Publications/Archives/CJP/2005/february/cjp-feb-05-V10-khazaal-OR.pdf
OBJECTIVE: Depersonalization is a fascinating clinical phenomenon referring to a self-consciousness disorder, characterized by emotional detachment from one's own feelings, thoughts, or actions. This article intends to summarize the current literature in this area. METHOD: Using the Medline data base, we reviewed literature addressing the clinical, etiology, nosology, physiopathology, and treatment of depersonalization. CONCLUSIONS: Derealization means that perception of the world and of external reality are altered. These 2 phenomena are often associated. They are not specific to any psychiatric entity and are reported in many different psychiatric syndromes. Many factors, including use of different substances, are involved in their onset. The physiopathology is still little known. However, some conceptual models suggest partial amygdala inhibition combined with activation of other amygdaloid structures. A serotoninergic functioning impairment is indicated in different pharmacologic studies. Different psychotropic drugs, especially serotoninergic antidepressants, have been proposed for pharmacotherapy; however, there are no conclusive randomized studies, and the contribution of psychotherapy in treating these patients is still questioned
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