Deciphering factors linked with reduced SARS-CoV-2 susceptibility in the Swiss HIV Cohort Study.

Abela, I.A.; Hauser, A.; Schwarzmüller, M.; Pasin, C.; Kusejko, K.; Epp, S.; Cavassini, M.; Battegay, M.; Rauch, A.; Calmy, A.; Notter, J.; Bernasconi, E.; Fux, C.A.; Leuzinger, K.; Perreau, M.; Ramette, A.; Gottschalk, J.; Schindler, E.; Wepf, A.; Marconato, M.; Manz, M.G.; Frey, B.M.; Braun, D.L.; Huber, M.; Günthard, H.F.; Trkola, A.; Kouyos, R.D.

doi:10.1093/infdis/jiae002

Deciphering factors linked with reduced SARS-CoV-2 susceptibility in the Swiss HIV Cohort Study.

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Serval ID

serval:BIB_F53FC91CC440

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Deciphering factors linked with reduced SARS-CoV-2 susceptibility in the Swiss HIV Cohort Study.

Journal

The Journal of infectious diseases

Author(s)

Abela I.A., Hauser A., Schwarzmüller M., Pasin C., Kusejko K., Epp S., Cavassini M., Battegay M., Rauch A., Calmy A., Notter J., Bernasconi E., Fux C.A., Leuzinger K., Perreau M., Ramette A., Gottschalk J., Schindler E., Wepf A., Marconato M., Manz M.G., Frey B.M., Braun D.L., Huber M., Günthard H.F., Trkola A., Kouyos R.D.

Working group(s)

Swiss HIV Cohort Study

Contributor(s)

Abela I., Aebi-Popp K., Anagnostopoulos A., Battegay M., Bernasconi E., Braun D.L., Bucher H.C., Calmy A., Cavassini M., Ciuffi A., Dollenmaier G., Egger M., Elzi L., Fehr J., Fellay J., Furrer H., Fux C.A., Günthard H.F., Hachfeld A., Haerry D., Hasse B., Hirsch H.H., Hoffmann M., Hösli I., Huber M., Jackson-Perry D., Kahlert C.R., Kaiser L., Keiser O., Klimkait T., Kouyos R.D., Kovari H., Kusejko K., Labhardt N., Leuzinger K., de Tejada B.M., Marzolini C., Metzner K.J., Müller N., Nemeth J., Nicca D., Notter J., Paioni P., Pantaleo G., Perreau M., Rauch A., Salazar-Vizcaya L., Schmid P., Speck R., Stöckle M., Tarr P., Trkola A., Wandeler G., Weisser M., Yerly S.

ISSN

1537-6613 (Electronic)

ISSN-L

0022-1899

Publication state

In Press

Peer-reviewed

Oui

Language

english

Notes

Publication types: Journal Article
Publication Status: aheadofprint

Abstract

Factors influencing susceptibility to SARS-CoV-2 remain to be resolved. Using data of the Swiss HIV Cohort Study (SHCS) on 6,270 people with HIV (PWH) and serologic assessment for SARS-CoV-2 and circulating-human-coronavirus (HCoV) antibodies, we investigated the association of HIV-related and general parameters with SARS-CoV-2 infection.
We analyzed SARS-CoV-2 PCR-tests, COVID-19 related hospitalizations, and deaths reported to the SHCS between January 1, 2020 and December 31, 2021. Antibodies to SARS-CoV-2 and HCoVs were determined in pre-pandemic (2019) and pandemic (2020) bio-banked plasma and compared to HIV-negative individuals. We applied logistic regression, conditional logistic regression, and Bayesian multivariate regression to identify determinants of SARS-CoV-2 infection and Ab responses to SARS-CoV-2 in PWH.
No HIV-1-related factors were associated with SARS-CoV-2 acquisition. High pre-pandemic HCoV antibodies were associated with a lower risk of subsequent SARS-CoV-2 infection and with higher SARS-CoV-2 antibody responses upon infection. We observed a robust protective effect of smoking on SARS-CoV-2-infection risk (aOR= 0.46 [0.38,0.56], p=2.6*10-14), which occurred even in previous smokers, and was highest for heavy smokers.
Our findings of two independent protective factors, smoking and HCoV antibodies, both affecting the respiratory environment, underscore the importance of the local immune milieu in regulating susceptibility to SARS-CoV-2.

Keywords

Hiv, Pwh, SARS-CoV-2, endemic human coronaviruses, pre-existing immunity, smoking, HIV, PWH

OAI-PMH

oai:serval.unil.ch:BIB_F53FC91CC440

DOI

10.1093/infdis/jiae002

Pubmed

38227786

Web of science

001155515800001

Open Access

Yes