Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells

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Serval ID
serval:BIB_F50DFD71903B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Production externe
Title
Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells
Journal
Nature
Author(s)
Piomelli  D., Volterra  A., Dale  N., Siegelbaum  S. A., Kandel  E. R., Schwartz  J. H., Belardetti  F.
ISSN
0028-0836 (Print)
Publication state
Published
Issued date
07/1987
Volume
328
Number
6125
Pages
38-43
Notes
Journal Article
Research Support, U.S. Gov't, P.H.S. --- Old month value: Jul 2-8
Abstract
Biochemical and biophysical studies on Aplysia sensory neurons indicate that inhibitory responses to the molluscan peptide FMRFamide are mediated by lipoxygenase metabolites of arachidonic acid. These compounds are a new class of second messengers in neurons.
Keywords
Animals Aplysia/*physiology Arachidonic Acid Arachidonic Acids/*metabolism/pharmacology Electrophysiology FMRFamide Hydroxy Acids/metabolism Hydroxyeicosatetraenoic Acids/physiology Ion Channels/drug effects/physiology *Leukotrienes Lipoxygenase/*metabolism Neurons, Afferent/drug effects/*physiology Neuropeptides/pharmacology Phospholipases/antagonists & inhibitors Synapses/*physiology
DOI
10.1038/328038a0
Pubmed
2439918
Web of science
A1987H995400045
Create date
24/01/2008 14:37
Last modification date
20/08/2019 16:21
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