Monocarboxylate transporters in the brain and in cancer.
Details
State: Public
Version: Final published version
Serval ID
serval:BIB_F4F513838C06
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Monocarboxylate transporters in the brain and in cancer.
Journal
Biochimica et Biophysica Acta. Molecular Cell Research
ISSN
0167-4889
ISSN-L
1879-2596
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
1863
Number
10
Pages
2481-2497
Language
english
Abstract
Monocarboxylate transporters (MCTs) constitute a family of 14 members among which MCT1-4 facilitate the passive transport of monocarboxylates such as lactate, pyruvate and ketone bodies together with protons across cell membranes. Their anchorage and activity at the plasma membrane requires interaction with chaperon protein such as basigin/CD147 and embigin/gp70. MCT1-4 are expressed in different tissues where they play important roles in physiological and pathological processes. This review focuses on the brain and on cancer. In the brain, MCTs control the delivery of lactate, produced by astrocytes, to neurons, where it is used as an oxidative fuel. Consequently, MCT dysfunctions are associated with pathologies of the central nervous system encompassing neurodegeneration and cognitive defects, epilepsy and metabolic disorders. In tumors, MCTs control the exchange of lactate and other monocarboxylates between glycolytic and oxidative cancer cells, between stromal and cancer cells and between glycolytic cells and endothelial cells. Lactate is not only a metabolic waste for glycolytic cells and a metabolic fuel for oxidative cells, but it also behaves as a signaling agent that promotes angiogenesis and as an immunosuppressive metabolite. Because MCTs gate the activities of lactate, drugs targeting these transporters have been developed that could constitute new anticancer treatments. This article is part of a Special Issue entitled: Mitochondrial Channels edited by Pierre Sonveaux, Pierre Maechler and Jean-Claude Martinou.
Keywords
Metabolic cooperation, Lactate shuttle, Neurons, Astrocytes, Tumor cells, Tumor microenvironment
Pubmed
Web of science
Open Access
Yes
Create date
20/01/2015 19:29
Last modification date
20/08/2019 17:21