Additive effects of rapamycin and aspirin on dendritic cell allostimulatory capacity.

Détails

ID Serval
serval:BIB_F4E32BE7E1F8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Additive effects of rapamycin and aspirin on dendritic cell allostimulatory capacity.
Périodique
Immunopharmacology and Immunotoxicology
Auteur(s)
Roehrich M.E., Wyss J.C., Kumar R., Pascual M., Golshayan D., Vassalli G.
ISSN
1532-2513 (Electronic)
ISSN-L
0892-3973
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
37
Numéro
5
Pages
434-441
Langue
anglais
Résumé
Acting as antigen presenting cells, mature dendritic cells (DCs) initiate both innate and adaptive alloimmune responses. However, immature DCs are weak immunostimulators and mediate tolerogenic effects under certain conditions. Tolerogenic activities of immature DCs can be enhanced by pharmacological agents. Here, we compared pharmacological DC preconditioning with rapamycin and aspirin, applied alone or in combination, on LPS-induced DC maturation and T-cell allostimulatory capacity. Preconditioning with aspirin but not rapamycin tended to reduce the number of mouse bone marrow-derived immature DCs expressing CD40 and major histocompatibility complex class II molecules upon LPS stimulation. Conversely, DC preconditioning with rapamycin, but not aspirin, reduced T-cell alloproliferative responses. A combination of rapamycin and aspirin was more effective than either drug applied alone with respect to inhibition of T-cell alloproliferation. The two agents in combination reduced numbers of CD4(+)IFN-γ(+) Th1 and CD4(+)IL-17(+) Th17 effector cells while maintaining Foxp3(+) regulatory T cells. These results suggest aspirin may moderately enhance rapamycin-mediated inhibition of DC allostimulatory capacity.
Pubmed
Création de la notice
27/11/2015 13:13
Dernière modification de la notice
20/08/2019 16:21
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