Maternal exposure to polychlorinated biphenyls and the secondary sex ratio: an occupational cohort study

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State: Public
Version: Final published version
Serval ID
serval:BIB_F47B0DF1475D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Maternal exposure to polychlorinated biphenyls and the secondary sex ratio: an occupational cohort study
Journal
Environmental Health
Author(s)
Rocheleau Carissa M., Bertke Stephen ., Deddens James A., Ruder Avima M., Lawson Christina C., Waters Martha A., Hopf Nancy B., Riggs Margaret A., Whelan Elizabeth A.
ISSN
1476-069X (Electronic)
ISSN-L
1476-069X
Publication state
Published
Issued date
18/03/2011
Peer-reviewed
Oui
Volume
10
Pages
20
Language
english
Notes
Publication types: Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
Publication Status: epublish
Abstract
Though commercial production of polychlorinated biphenyls was banned in the United States in 1977, exposure continues due to their environmental persistence. Several studies have examined the association between environmental polychlorinated biphenyl exposure and modulations of the secondary sex ratio, with conflicting results.
Our objective was to evaluate the association between maternal preconceptional occupational polychlorinated biphenyl exposure and the secondary sex ratio.
We examined primipara singleton births of 2595 women, who worked in three capacitor plants at least one year during the period polychlorinated biphenyls were used. Cumulative estimated maternal occupational polychlorinated biphenyl exposure at the time of the infant's conception was calculated from plant-specific job-exposure matrices. A logistic regression analysis was used to evaluate the association between maternal polychlorinated biphenyl exposure and male sex at birth (yes/no).
Maternal body mass index at age 20, smoking status, and race did not vary between those occupationally exposed and those unexposed before the child's conception. Polychlorinated biphenyl-exposed mothers were, however, more likely to have used oral contraceptives and to have been older at the birth of their first child than non-occupationally exposed women. Among 1506 infants liveborn to polychlorinated biphenyl-exposed primiparous women, 49.8% were male; compared to 49.9% among those not exposed (n = 1089). Multivariate analyses controlling for mother's age and year of birth found no significant association between the odds of a male birth and mother's cumulative estimated polychlorinated biphenyl exposure to time of conception.
Based on these data, we find no evidence of altered sex ratio among children born to primiparous polychlorinated biphenyl-exposed female workers.

Keywords
Adolescent, Adult, Chemical Industry, Cohort Studies, Female, Humans, Indiana/epidemiology, Male, Massachusetts/epidemiology, Maternal Exposure/adverse effects, Multivariate Analysis, New York/epidemiology, Occupational Exposure, Polychlorinated Biphenyls/toxicity, Retrospective Studies, Sex Ratio, Surveys and Questionnaires, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
10/08/2011 16:21
Last modification date
20/08/2019 16:21
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