Antigenicity and immunogenicity of Melan-A/MART-1 derived peptides as targets for tumor reactive CTL in human melanoma.

Détails

ID Serval
serval:BIB_F417556ABB91
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Antigenicity and immunogenicity of Melan-A/MART-1 derived peptides as targets for tumor reactive CTL in human melanoma.
Périodique
Immunological reviews
Auteur(s)
Romero P., Valmori D., Pittet M.J., Zippelius A., Rimoldi D., Lévy F., Dutoit V., Ayyoub M., Rubio-Godoy V., Michielin O., Guillaume P., Batard P., Luescher I.F., Lejeune F., Liénard D., Rufer N., Dietrich P.Y., Speiser D.E., Cerottini J.C.
ISSN
0105-2896
Statut éditorial
Publié
Date de publication
2002
Peer-reviewed
Oui
Volume
188
Pages
81-96
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Some cancer patients mount spontaneous T- and B-cell responses against their tumor cells. Autologous tumor reactive CD8 cytolytic T lymphocyte (CTL) and CD4 T-cell clones as well as antibodies from these patients have been used for the identification of genes encoding the target antigens. This knowledge opened the way for new approaches to the immunotherapy of cancer. In this review, we describe the characterization of the structure-function properties of the melanocyte/melanoma tumor antigen Melan-A/MART-1, the assessment of the T-cell repertoire available against this antigen in healthy individuals, and the analysis of naturally acquired and/or vaccine-induced CTL responses to this antigen in patients with metastatic melanoma.
Mots-clé
Amino Acid Sequence, Antigen Presentation, Antigens, Neoplasm/chemistry, Antigens, Neoplasm/immunology, Cancer Vaccines/immunology, Cancer Vaccines/therapeutic use, Cytotoxicity, Immunologic, Epitopes, T-Lymphocyte/immunology, HLA-A2 Antigen/immunology, Humans, Immunity, Innate, Immunotherapy, Active, Melanoma/immunology, Melanoma/secondary, Molecular Sequence Data, Neoplasm Proteins/chemistry, Neoplasm Proteins/immunology, Peptide Fragments/immunology, Protein Interaction Mapping, Receptors, Antigen, T-Cell/immunology, Structure-Activity Relationship, T-Lymphocytes, Cytotoxic/immunology, Treatment Outcome
Pubmed
Web of science
Création de la notice
28/01/2008 12:17
Dernière modification de la notice
03/03/2018 22:43
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