Multiple functions of Notch signaling in self-renewing organs and cancer

Détails

ID Serval
serval:BIB_F4023301891A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Multiple functions of Notch signaling in self-renewing organs and cancer
Périodique
FEBS Letters
Auteur(s)
Wilson  A., Radtke  F.
ISSN
0014-5793 (Print)
Statut éditorial
Publié
Date de publication
05/2006
Volume
580
Numéro
12
Pages
2860-8
Notes
Journal Article
Review --- Old month value: May 22
Résumé
In recent years a substantial body of evidence has accumulated to support the notion that signaling pathways known to be important during embryonic development play important roles in regulating self-renewing tissues. Moreover, the same pathways are often deregulated during tumorigenesis due to mutations of key elements of these pathways. The Notch signaling cascade meets all of the above-mentioned criteria. We discuss here the pleiotropic roles of the Notch signaling pathway in three different self-renewing organs (intestine, hematopoietic system and skin) and how its deregulation is involved in tumorigenesis.
Mots-clé
Animals Cell Differentiation Hematopoiesis Humans Intestines/cytology Neoplasms/*metabolism/pathology Receptors, Notch/*metabolism *Signal Transduction
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 12:39
Dernière modification de la notice
09/05/2019 3:27
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