Interactions immunoendocriniennes au niveau hypothalamo-hypophysaire [Immuno-endocrine interactions at the hypothalamo-hypophyseal level]

Détails

ID Serval
serval:BIB_F3E740EA61B5
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Interactions immunoendocriniennes au niveau hypothalamo-hypophysaire [Immuno-endocrine interactions at the hypothalamo-hypophyseal level]
Périodique
Annales d'Endocrinologie
Auteur(s)
Gaillard R.C.
ISSN
0003-4266
Statut éditorial
Publié
Date de publication
1995
Peer-reviewed
Oui
Volume
56
Numéro
6
Pages
561-566
Langue
français
Notes
Publication types: English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
Résumé
The endocrine and immune systems are interrelated via a bidirectional network in which hormones modulate immune function and in turn, immune responses are reflected in endocrine changes. Stimulated immune cells produce cytokines and these substances have been shown to modulate the corticotroph, somatotroph, gonadotroph and thyreotroph axes. Interleukin-1, interleukin-6 and tumor necrosis factor alpha can either stimulate or inhibit the corticotroph axis by acting at all three levels, the hypothalamus, the pituitary gland and the adrenal glands. The hypothalamic effects of the cytokines are fast and mediated by the prostaglandins and by the nitric oxide (NO) pathway. In contrast, the cytokines at pituitary level have a slow onset of effect and their effects are not mediated by the prostaglandins or by the NO pathway. The immuno-neuroendocrine interactions are involved in numerous physiological and pathophysiological conditions. Thus, the interactions with the hypothalamo-pituitary-adrenal axis may represent an important feedback mechanism, through which the immune system by stimulating the production of immunosuppressive glucocorticoids avoids an overshoot of the inflammatory response.
Mots-clé
Animals, Cytokines/physiology, Endocrine Glands/physiology, Humans, Hypothalamo-Hypophyseal System/physiology, Hypothalamo-Hypophyseal System/physiopathology, Immune System/physiology, Inflammation/physiopathology, Pituitary-Adrenal System/physiology, Pituitary-Adrenal System/physiopathology
Pubmed
Web of science
Création de la notice
15/02/2008 17:58
Dernière modification de la notice
03/03/2018 22:43
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