Description d'un melanome de l'uvee dans le cadre d'une neurofibromatose de type 2. [Choroidal melanoma in neurofibromatosis type 2: description of a case]

Détails

ID Serval
serval:BIB_F3E58BC62EF4
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Description d'un melanome de l'uvee dans le cadre d'une neurofibromatose de type 2. [Choroidal melanoma in neurofibromatosis type 2: description of a case]
Périodique
Journal Français d'Ophtalmologie
Auteur(s)
Mataftsi  A., Zografos  L., Chamot  L., Schalenbourg  A.
ISSN
0181-5512 (Print)
Statut éditorial
Publié
Date de publication
05/2003
Volume
26
Numéro
5
Pages
477-80
Notes
Case Reports
English Abstract
Journal Article --- Old month value: May
Résumé
To the best of our knowledge this is the first description of a choroidal melanoma with documented growth in neurofibromatosis type 2 (NF2). A 20-year-old patient with NF2 presenting deafness due to bilateral acoustic neurinomas and unilateral amaurosis due to a meningioma of the optic nerve developed a pigmented parapapillary choroidal tumor. Despite signs indicating the diagnosis of a melanoma, periodic observation was chosen in order to postpone functional amputation following optic nerve irradiation. The tumor growth was slow during the 5 years that followed, and once progression became rapid, the tumor was treated by accelerated proton beam radiotherapy. One year later, visual acuity diminished due to actinic optic neuropathy and was stabilized at 0.3 for the 2 following years. The tumor presented objective signs of regression, and no sign of metastatic disease was observed. The therapeutic approach in this case provided local control of the tumor while preserving useful visual function.
Mots-clé
Adult Choroid Neoplasms/*complications/diagnosis/pathology/surgery Disease Progression Female Humans Melanoma/*complications/diagnosis/pathology/surgery Neurofibromatosis 2/*complications Optic Nerve/radiation effects Radiotherapy/methods Treatment Outcome
Pubmed
Web of science
Création de la notice
28/01/2008 14:10
Dernière modification de la notice
20/03/2018 13:25
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