Article: article from journal or magazin.
IL-21R on T cells is critical for sustained functionality and control of chronic viral infection.
Chronic viral infection is often associated with the dysfunction of virus-specific T cells. Our studies using Il21r-deficient (Il21r-/-) mice now suggest that interleukin-21 (IL-21) is critical for the long-term maintenance and functionality of CD8+ T cells and the control of chronic lymphocytic choriomeningitis virus infection in mice. Cell-autonomous IL-21 receptor (IL-21R)-dependent signaling by CD8+ T cells was required for sustained cell proliferation and cytokine production during chronic infection. Il21r-/- mice showed normal CD8+ T cell expansion, effector function, memory homeostasis, and recall responses during acute and after resolved infection with several other nonpersistent viruses. These data suggest that IL-21R signaling is required for the maintenance of polyfunctional T cells during chronic viral infections and have implications for understanding the immune response to other persisting antigens, such as tumors.
Animals, CD8-Positive T-Lymphocytes/immunology, Chronic Disease, Humans, Immunologic Memory, Interferon-gamma/biosynthesis, Lymphocytic Choriomeningitis/immunology, Mice, Mice, Inbred C57BL, Peptide Fragments/biosynthesis, Receptors, Interleukin-21/immunology, Signal Transduction
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