Molecular basis of host-pathogen interaction in septic shock

Details

Serval ID
serval:BIB_F3B065C03E9F
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Molecular basis of host-pathogen interaction in septic shock
Journal
Current Opinion in Microbiology
Author(s)
Heumann  D., Glauser  M. P., Calandra  T.
ISSN
1369-5274 (Print)
Publication state
Published
Issued date
02/1998
Volume
1
Number
1
Pages
49-55
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Feb
Abstract
Specific mechanisms of recognition of microbial products have been developed by host cells. Among these mechanisms, recognition of lipopolysaccharide of Gram-negative bacteria by CD14, a glycoprotein expressed at the surface of myelomonocytic cells, plays a major role. There is increasing evidence that CD14 also serves as a receptor for other microbial products including peptidoglycan of Gram-positive bacteria. A common theme is that CD14 represents a key molecule in innate immunity. Recognition of microbial products by host cells leads to cell activation and production of a large array of mediators that are necessary for the development of controlled inflammatory processes. When the activation process is out of control, such as in septic shock, these mediators can be detrimental to the host.
Keywords
Animals Antigens, CD14/immunology/metabolism Bacteria/*immunology Bacterial Infections/*immunology/microbiology Humans Inflammation Lipopolysaccharides/metabolism Peptidoglycan/metabolism Shock, Septic/*immunology/microbiology
Pubmed
Web of science
Create date
25/01/2008 13:28
Last modification date
20/08/2019 16:20
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