Molecular basis of host-pathogen interaction in septic shock

Détails

ID Serval
serval:BIB_F3B065C03E9F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Molecular basis of host-pathogen interaction in septic shock
Périodique
Current Opinion in Microbiology
Auteur(s)
Heumann  D., Glauser  M. P., Calandra  T.
ISSN
1369-5274 (Print)
Statut éditorial
Publié
Date de publication
02/1998
Volume
1
Numéro
1
Pages
49-55
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Feb
Résumé
Specific mechanisms of recognition of microbial products have been developed by host cells. Among these mechanisms, recognition of lipopolysaccharide of Gram-negative bacteria by CD14, a glycoprotein expressed at the surface of myelomonocytic cells, plays a major role. There is increasing evidence that CD14 also serves as a receptor for other microbial products including peptidoglycan of Gram-positive bacteria. A common theme is that CD14 represents a key molecule in innate immunity. Recognition of microbial products by host cells leads to cell activation and production of a large array of mediators that are necessary for the development of controlled inflammatory processes. When the activation process is out of control, such as in septic shock, these mediators can be detrimental to the host.
Mots-clé
Animals Antigens, CD14/immunology/metabolism Bacteria/*immunology Bacterial Infections/*immunology/microbiology Humans Inflammation Lipopolysaccharides/metabolism Peptidoglycan/metabolism Shock, Septic/*immunology/microbiology
Pubmed
Web of science
Création de la notice
25/01/2008 14:28
Dernière modification de la notice
03/03/2018 22:42
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