A preclinical model for identifying rats at risk of alcohol use disorder.

Détails

Ressource 1Télécharger: s41598-017-09801-1.pdf (1272.17 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_F3999F21A3C1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A preclinical model for identifying rats at risk of alcohol use disorder.
Périodique
Scientific reports
Auteur(s)
Jadhav K.S., Magistretti P.J., Halfon O., Augsburger M., Boutrel B.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Statut éditorial
Publié
Date de publication
25/08/2017
Peer-reviewed
Oui
Volume
7
Numéro
1
Pages
9454
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
Alcohol use is one of the world's leading causes of death and disease, although only a small proportion of individuals develop persistent alcohol use disorder (AUD). The identification of vulnerable individuals prior to their chronic intoxication remains of highest importance. We propose here to adapt current methodologies for identifying rats at risk of losing control over alcohol intake by modeling diagnostic criteria for AUD: inability to abstain during a signaled period of reward unavailability, increased motivation assessed in a progressive effortful task and persistent alcohol intake despite aversive foot shocks. Factor analysis showed that these three addiction criteria loaded on one underlying construct indicating that they represent a latent construct of addiction trait. Further, not only vulnerable rats displayed higher ethanol consumption, and higher preference for ethanol over sweetened solutions, but they also exhibited pre-existing higher anxiety as compared to resilient rats. In conclusion, the present preclinical model confirms that development of an addiction trait not only requires prolonged exposure to alcohol, but also depends on endophenotype like anxiety that predispose a minority of individuals to lose control over alcohol consumption.
Mots-clé
Alcohol Drinking/adverse effects, Alcoholism/physiopathology, Alcoholism/psychology, Animals, Anxiety/physiopathology, Anxiety/psychology, Behavior, Animal, Conditioning, Operant, Disease Models, Animal, Ethanol/adverse effects, Humans, Male, Rats, Rats, Wistar, Reward, Risk, Self Administration
Pubmed
Web of science
Open Access
Oui
Création de la notice
01/09/2017 7:48
Dernière modification de la notice
20/08/2019 16:20
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