Mapping and characterization of positive and negative BOLD responses to visual stimulation in multiple brain regions at 7T.

Détails

ID Serval
serval:BIB_F389BD3647B9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Mapping and characterization of positive and negative BOLD responses to visual stimulation in multiple brain regions at 7T.
Périodique
Human brain mapping
Auteur(s)
Jorge J., Figueiredo P., Gruetter R., van der Zwaag W.
ISSN
1097-0193 (Electronic)
ISSN-L
1065-9471
Statut éditorial
Publié
Date de publication
06/2018
Peer-reviewed
Oui
Volume
39
Numéro
6
Pages
2426-2441
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
External stimuli and tasks often elicit negative BOLD responses in various brain regions, and growing experimental evidence supports that these phenomena are functionally meaningful. In this work, the high sensitivity available at 7T was explored to map and characterize both positive (PBRs) and negative BOLD responses (NBRs) to visual checkerboard stimulation, occurring in various brain regions within and beyond the visual cortex. Recently-proposed accelerated fMRI techniques were employed for data acquisition, and procedures for exclusion of large draining vein contributions, together with ICA-assisted denoising, were included in the analysis to improve response estimation. Besides the visual cortex, significant PBRs were found in the lateral geniculate nucleus and superior colliculus, as well as the pre-central sulcus; in these regions, response durations increased monotonically with stimulus duration, in tight covariation with the visual PBR duration. Significant NBRs were found in the visual cortex, auditory cortex, default-mode network (DMN) and superior parietal lobule; NBR durations also tended to increase with stimulus duration, but were significantly less sustained than the visual PBR, especially for the DMN and superior parietal lobule. Responses in visual and auditory cortex were further studied for checkerboard contrast dependence, and their amplitudes were found to increase monotonically with contrast, linearly correlated with the visual PBR amplitude. Overall, these findings suggest the presence of dynamic neuronal interactions across multiple brain regions, sensitive to stimulus intensity and duration, and demonstrate the richness of information obtainable when jointly mapping positive and negative BOLD responses at a whole-brain scale, with ultra-high field fMRI.
Mots-clé
Adult, Brain/blood supply, Brain/diagnostic imaging, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Linear Models, Magnetic Resonance Imaging, Male, Oxygen/blood, Photic Stimulation, Young Adult, ICA denoising, draining veins, fMRI, multisensory, negative BOLD, visual stimulation
Pubmed
Web of science
Création de la notice
15/04/2019 9:05
Dernière modification de la notice
20/08/2019 17:20
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