Large granular lymphocyte expansion after allogeneic hematopoietic stem cell transplant is associated with a cytomegalovirus reactivation and shows an indolent outcome.

Details

Serval ID
serval:BIB_F33EA8AD77FD
Type
Article: article from journal or magazin.
Collection
Publications
Title
Large granular lymphocyte expansion after allogeneic hematopoietic stem cell transplant is associated with a cytomegalovirus reactivation and shows an indolent outcome.
Journal
Biology of blood and marrow transplantation
Author(s)
Nann-Rütti S., Tzankov A., Cantoni N., Halter J., Heim D., Tsakiris D., Arber C., Buser A., Gratwohl A., Tichelli A., Rovó A.
ISSN
1523-6536 (Electronic)
ISSN-L
1083-8791
Publication state
Published
Issued date
11/2012
Peer-reviewed
Oui
Volume
18
Number
11
Pages
1765-1770
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Expansions of CD3+ large granular lymphocytes (LGLs) after allogeneic hematopoietic stem cell transplantation (HSCT) have been described. We sought to evaluate incidence, characteristics, and clinical significance of persistent T cell (T-)LGL after HSCT. Fourteen of 215 recipients (7%) were diagnosed with LGL expansions. Thirteen showed a CD3+/CD8+ immunophenotype, 5 of them with clonal TCR-γ rearrangement. The lymphocytes appeared at a median of 16 months (range, 3-58 months) after HSCT and lasted for a median time of 31 months (range, 2-179 months). Cytomegalovirus (CMV) reactivation (P = .001) and acute graft-versus-host disease (aGVHD) were associated with LGL expansion (P = .02). In the multivariate analysis, only CMV reactivation showed a significant association with T-LGL expansion (relative risk [RR]: 5.063; 95% confidence interval [CI]: 1.586-16.160; P = .006). The observed posttransplantation LGL expansions, even if monoclonal, showed a chronic, indolent course. Our data indicate that such expansions may be considered as an expression of chronic stimulation, triggered by CMV reactivation rather than a malignant transformation.
Keywords
Acute Disease, Adolescent, Adult, Aged, CD3 Complex/immunology, CD4-Positive T-Lymphocytes/immunology, CD4-Positive T-Lymphocytes/pathology, CD8-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/pathology, Child, Cross-Sectional Studies, Cytomegalovirus/physiology, Cytomegalovirus Infections/etiology, Cytomegalovirus Infections/immunology, Cytomegalovirus Infections/pathology, Cytomegalovirus Infections/virology, Female, Graft vs Host Disease/etiology, Graft vs Host Disease/immunology, Graft vs Host Disease/pathology, Hematopoietic Stem Cell Transplantation/adverse effects, Humans, Immunophenotyping, Male, Middle Aged, Risk Factors, Transplantation, Homologous, Virus Activation
Pubmed
Web of science
Open Access
Yes
Create date
01/11/2019 9:59
Last modification date
02/11/2019 6:26
Usage data