EEG recording latency in critically ill patients: Impact on outcome. An analysis of a randomized controlled trial (CERTA).
Details
State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_F32F6B846EF2
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
EEG recording latency in critically ill patients: Impact on outcome. An analysis of a randomized controlled trial (CERTA).
Journal
Clinical neurophysiology
ISSN
1872-8952 (Electronic)
ISSN-L
1388-2457
Publication state
Published
Issued date
07/2022
Peer-reviewed
Oui
Volume
139
Pages
23-27
Language
english
Notes
Publication types: Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
To assess, in adults with acute consciousness impairment, the impact of latency between hospital admission and EEG recording start, and their outcome.
We reviewed data of the CERTA trial (NCT03129438) and explored correlations between EEG recording latency and mortality, Cerebral Performance Categories (CPC), and modified Rankin Scale (mRS) at 6 months, considering other variables, using uni- and multivariable analyses.
In univariable analysis of 364 adults, median latency between admission and EEG recordings was comparable between surviving (61.1 h; IQR: 24.3-137.7) and deceased patients (57.5 h; IQR: 22.3-141.1); p = 0.727. This did not change after adjusting for potential confounders, such as lower Glasgow Coma Score on enrolment (p < 0.001) and seizure or status epilepticus detection (p < 0.001). There was neither any correlation between EEG latency and mRS (rho 0.087, p 0.236), nor with CPC (rho = 0.027, p = 0.603).
This analysis shows no correlation between delays of EEG recordings and mortality or functional outcomes at 6 months in critically ill adults.
These findings might suggest that in critically ill adults mortality correlates with underlying brain injury rather than EEG delay.
We reviewed data of the CERTA trial (NCT03129438) and explored correlations between EEG recording latency and mortality, Cerebral Performance Categories (CPC), and modified Rankin Scale (mRS) at 6 months, considering other variables, using uni- and multivariable analyses.
In univariable analysis of 364 adults, median latency between admission and EEG recordings was comparable between surviving (61.1 h; IQR: 24.3-137.7) and deceased patients (57.5 h; IQR: 22.3-141.1); p = 0.727. This did not change after adjusting for potential confounders, such as lower Glasgow Coma Score on enrolment (p < 0.001) and seizure or status epilepticus detection (p < 0.001). There was neither any correlation between EEG latency and mRS (rho 0.087, p 0.236), nor with CPC (rho = 0.027, p = 0.603).
This analysis shows no correlation between delays of EEG recordings and mortality or functional outcomes at 6 months in critically ill adults.
These findings might suggest that in critically ill adults mortality correlates with underlying brain injury rather than EEG delay.
Keywords
Adult, Analysis of Variance, Critical Illness, Electroencephalography/statistics & numerical data, Humans, Pyridines, Seizures/complications, Status Epilepticus, Time Factors, Electroencephalography, Intensive care unit, Prognosis, Seizures, Status epilepticus
Pubmed
Web of science
Open Access
Yes
Create date
16/05/2022 8:30
Last modification date
16/04/2024 6:25
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