HIV-1 latent reservoir: size matters.

Détails

Ressource 1Télécharger: 28757894_BIB_F2B9E7CAEBE7.pdf (1879.89 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_F2B9E7CAEBE7
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
HIV-1 latent reservoir: size matters.
Périodique
Future virology
Auteur(s)
Hodel F., Patxot M., Snäkä T., Ciuffi A.
ISSN
1746-0794 (Print)
ISSN-L
1746-0794
Statut éditorial
Publié
Date de publication
12/2016
Peer-reviewed
Oui
Volume
11
Numéro
12
Pages
785-794
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
More than 35 million people remain infected with HIV-1. Upon antiretroviral therapy cessation, HIV-1-positive individuals systematically fail to achieve sustained virological remission, revealing the presence of a reservoir. This reservoir takes into account anatomical sanctuaries where HIV-1 continues to replicate, and latently infected cells also known as the latent reservoir (LR). A better understanding of the nature and features of the LR and its quantification are crucial to evaluate the efficiency of therapeutic strategies aiming at purging HIV-1. Culture- and PCR-based assays have already been implemented to measure the LR, and new assays are continuously being developed. In this review, we will discuss these methods highlighting the difficulties to accurately measure the LR, one main obstacle in curing HIV-1.

Mots-clé
DNA, HIV-1, RNA, assays, latent reservoir, quantification, size
Pubmed
Web of science
Création de la notice
08/08/2017 12:17
Dernière modification de la notice
08/05/2018 10:36
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