CD4/CD8 ratio and CD8 counts predict CD4 response in HIV-1-infected drug naive and in patients on cART.

Détails

Ressource 1Télécharger: medi-95-e5094.pdf (383.91 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_F2B466D58431
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
CD4/CD8 ratio and CD8 counts predict CD4 response in HIV-1-infected drug naive and in patients on cART.
Périodique
Medicine
Auteur(s)
Sauter R., Huang R., Ledergerber B., Battegay M., Bernasconi E., Cavassini M., Furrer H., Hoffmann M., Rougemont M., Günthard H.F., Held L.
Collaborateur(s)
and the Swiss HIV cohort study
ISSN
1536-5964 (Electronic)
ISSN-L
0025-7974
Statut éditorial
Publié
Date de publication
10/2016
Peer-reviewed
Oui
Volume
95
Numéro
42
Pages
e5094
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study ; Observational Study
Publication Status: ppublish
Résumé
Plasma HIV viral load is related to declining CD4 lymphocytes. The extent to which CD8 cells, in addition to RNA viral load, predict the depletion of CD4 cells is not well characterized so far. We examine if CD8 cell count is a prognostic factor for CD4 cell counts during an HIV infection.A longitudinal analysis is conducted using data from the Swiss HIV cohort study collected between January 2000 and October 2014. Linear mixed regression models were applied to observations from HIV-1-infected treatment naive patients (NAIVE) and cART-treated patients to predict the short-term evolution of CD4 cell counts. For each subgroup, it was quantified to which extent CD8 cell counts or CD4/CD8 ratios are prognostic factors for disease progression.In both subgroups, 2500 NAIVE and 8902 cART patients, past CD4 cells are positively (P < 0.0001) and past viral load is negatively (P < 0.0001) associated with the outcome. Including additionally past CD8 cell counts improves the fit significantly (P < 0.0001) and increases the marginal explained variation 31.7% to 40.7% for the NAIVE and from 44.1% to 50.7% for the cART group. The past CD4/CD8 ratio (instead of the past CD8 level) is positively associated with the outcome, increasing the explained variation further to 41.8% for NAIVE and 51.9% for cART.

Mots-clé
Antiretroviral Therapy, Highly Active/methods, CD4-CD8 Ratio, CD4-Positive T-Lymphocytes/pathology, CD8-Positive T-Lymphocytes/pathology, Disease Progression, Female, Follow-Up Studies, HIV Infections/diagnosis, HIV Infections/drug therapy, HIV Infections/virology, HIV-1/genetics, Humans, Male, Middle Aged, RNA, Viral/analysis, Retrospective Studies, Viral Load
Pubmed
Open Access
Oui
Création de la notice
07/12/2016 15:23
Dernière modification de la notice
09/05/2019 3:23
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