Retroviral infection of neonatal Peyer's patch lymphocytes: the mouse mammary tumor virus model.

Détails

ID Serval
serval:BIB_F28AFC10CD1E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Retroviral infection of neonatal Peyer's patch lymphocytes: the mouse mammary tumor virus model.
Périodique
Journal of Experimental Medicine
Auteur(s)
Karapetian O., Shakhov A.N., Kraehenbuhl J.P., Acha-Orbea H.
ISSN
0022-1007 (Print)
ISSN-L
0022-1007
Statut éditorial
Publié
Date de publication
1994
Volume
180
Numéro
4
Pages
1511-1516
Langue
anglais
Résumé
Mouse mammary tumor virus is known to infect newborn mice via mother's milk. A proposed key step for viral spread to the mammary gland is by the infection of lymphocytes. We show here that although in suckling mice retroviral proteins are found in all epithelial cells of the gut, viral DNA is exclusively detectable in the Peyer's patches. As early as 5 d after birth the infection leads to a superantigen response in the Peyer's patches but not in other lymphoid organs draining the intestine. Viral DNA can be detected before the superantigen response and becomes first evident in the Peyer's patches followed by mesenteric lymph nodes and finally all lymphoid organs.
Mots-clé
Animals, Animals, Newborn, Base Sequence, DNA, Viral/analysis, Lymphocytes/microbiology, Mammary Tumor Virus, Mouse/genetics, Mammary Tumor Virus, Mouse/immunology, Mice, Mice, Inbred BALB C, Molecular Sequence Data, Peyer's Patches/microbiology, Polymerase Chain Reaction, Retroviridae Infections/etiology, Superantigens/immunology, Tumor Virus Infections/etiology
Pubmed
Web of science
Création de la notice
24/01/2008 15:48
Dernière modification de la notice
03/03/2018 22:40
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