BDNF promoter I methylation correlates between post-mortem human peripheral and brain tissues.

Détails

ID Serval
serval:BIB_F277C661AF9E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
BDNF promoter I methylation correlates between post-mortem human peripheral and brain tissues.
Périodique
Neuroscience Research
Auteur(s)
Stenz L., Zewdie S., Laforge-Escarra T., Prados J., La Harpe R., Dayer A., Paoloni-Giacobino A., Perroud N., Aubry J.M.
ISSN
1872-8111
ISSN-L
0168-0102
Statut éditorial
Publié
Date de publication
2015
Volume
91
Pages
1-7
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Several psychiatric disorders have been associated with CpG methylation changes in CG rich promoters of the brain-derived neurotrophic factor (BDNF) mainly by extracting DNA from peripheral blood cells. Whether changes in peripheral DNA methylation can be used as a proxy for brain-specific alterations remains an open question. In this study we aimed to compare DNA methylation levels in BDNF promoter regions in human blood cells, muscle and brain regions using bisulfite-pyrosequencing. We found a significant correlation between the levels of BDNF promoter I methylation measured in quadriceps and vPFC tissues extracted from the same individuals (n = 98, Pearson, r = 0.48, p = 4.5 × 10(-7)). In the hippocampus, BDNF promoter I and IV methylation levels were strongly correlated (Pearson, n = 37, r = 0.74, p = 1.4 × 10(-7)). We found evidence for sex-dependent effect on BDNF promoter methylation levels in the various tissues and blood samples. Taken together, these data indicate a strong intra-individual correlation between peripheral and brain tissue. They also suggest that sex determines methylation patterns in BDNF promoter region across different types of tissue, including muscle, brain, and blood.
Mots-clé
BDNF, Epigenetics, Methylation, Prefrontal cortex, Promoter, Quadriceps
Pubmed
Web of science
Création de la notice
03/12/2014 16:49
Dernière modification de la notice
03/03/2018 22:40
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