Atypical coordination of cortical oscillations in response to speech in autism.

Détails

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Etat: Public
Version: Final published version
ID Serval
serval:BIB_F2610D613F61
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Atypical coordination of cortical oscillations in response to speech in autism.
Périodique
Frontiers in Human Neuroscience
Auteur(s)
Jochaut D., Lehongre K., Saitovitch A., Devauchelle A.D., Olasagasti I., Chabane N., Zilbovicius M., Giraud A.L.
ISSN
1662-5161 (Electronic)
ISSN-L
1662-5161
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
9
Pages
171
Langue
anglais
Notes
Publication types: Journal Article Publication Status: epublish
Résumé
Subjects with autism often show language difficulties, but it is unclear how they relate to neurophysiological anomalies of cortical speech processing. We used combined EEG and fMRI in 13 subjects with autism and 13 control participants and show that in autism, gamma and theta cortical activity do not engage synergistically in response to speech. Theta activity in left auditory cortex fails to track speech modulations, and to down-regulate gamma oscillations in the group with autism. This deficit predicts the severity of both verbal impairment and autism symptoms in the affected sample. Finally, we found that oscillation-based connectivity between auditory and other language cortices is altered in autism. These results suggest that the verbal disorder in autism could be associated with an altered balance of slow and fast auditory oscillations, and that this anomaly could compromise the mapping between sensory input and higher-level cognitive representations.
Pubmed
Web of science
Open Access
Oui
Création de la notice
01/05/2015 17:07
Dernière modification de la notice
20/08/2019 16:19
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