Interpreting Breast International Group (BIG) 1-98: a randomized, double-blind, phase III trial comparing letrozole and tamoxifen as adjuvant endocrine therapy for postmenopausal women with hormone receptor-positive, early breast cancer.
Details
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UNIL restricted access
State: Public
Version: Final published version
License: Not specified
Serval ID
serval:BIB_F24F2585D44E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Interpreting Breast International Group (BIG) 1-98: a randomized, double-blind, phase III trial comparing letrozole and tamoxifen as adjuvant endocrine therapy for postmenopausal women with hormone receptor-positive, early breast cancer.
Journal
Breast cancer research
Working group(s)
International Breast Cancer Study Group and BIG 1-98 Collaborative Group
Contributor(s)
Thürlimann B., Aebi S., Blacher L., Coates A.S., Cufer T., Forbes J., Gelber R.D., Giobbie-Hurder A., Goldhirsch A., Hiltbrunner A., Holmberg S.B., Maibach R., Martoni A., Mauriac L., MacGrogan G., Mouridsen H.T., Paridaens R., Phuong D., Price K.N., Rabaglio M., Rasmussen B.B., Regan M.M., Santoro A., Smith I.E., Wardley A., Viale G., Chaudri- Ross H.A., Segal S., Evans D.B., Aebi S., Coates A.S., Colleoni M., Collins J.P., Cortés Funes H., Gelber R.D., Goldhirsch A., Green M., Hiltbrunner A., Holmberg S.B., Karlsson P., Kössler I., Láng I., Lindtner J., Paganetti F., de Stoppani M., Rudenstam C.M., Senn H.J., Stahel R., Thürlimann B., Veronesi A., Castiglione M., Hiltbrunner A., Rabaglio M., Egli G., Hawle H., Cliff B., Ribeli-Hofmann S., Munarini F., Kammler R., Studer R., Ruepp B., Maibach R., Munarini N., Gelber R.D., Regan M.M., Price K.N., Giobbie-Hurder A., Keshaviah A., Litman H., Sun Z., Huang H., Somos L.J., Timmers B., Nickerson L., Blacher L., Heckman T., Belisle M., Caporale M., Celano J., Dalfonso L., Dooley L., Fischer S., Galloway K., Gould J., Hinkle R., Holody M., Jones G., Krall R., Lippert S., Meshulam J., Mundy L., Pavlov-Shapiro A., Scott K., Scott M., Shepard S., Swick J., Uhteg L., Weinbaum D., Westby C., Zielinski T., A B., Mallon E., Viale G., Dell'Orto P., Mastropasqua M., Del Curto B., Waldie E., van Hoomissen I., De Smet M., Trostmann U., Schmidt W., Bolton A., Hackl W., Snyder R.D., Chirgwin J., Forbes J.F., Coates A.S., Boyle F., Lindsay D., Preece D., Cowell J., Talbot D., Whipp A., Abell F., Basser R., Bell R., Brady B., Blakey D., Briggs P., Burns I., Campbell P., Chao M., Chirgwin J., Chua B., Clarke K., Collins J., De Boer R., Din J.C., Doig R., Dowling A., Drummond R., Efe N., Fan S.T., Francis M., Francis P., Ganju V., Gibbs P., Goss G., Green M., Gregory P., Griffiths J., Haines I., Henderson M., Holmes R., James P., Kiffler J., Lehman M., Leyden M., Lim L., Lindeman G., Lynch R., Mann B., McKendrick J., McLachlan S., McLennan R., Mitchell G., Mitra S., Murphy C., Parker I., Phillips K., Porter I., Richardson G., Scarlet J., Sewak S., Shapiro J., Snyder R., Stanley R., Steer C., Stoney D., Strickland A., Toner G., Underhill C., White K., White M., Wirth A., Wong S., Byram D., Byard I., Della-Fiorentina S., Goldrick A., Hovey E., Moylan E., Segelov E., Chan A., Buck M., Hastrich D., Ingram D., Van Hazel G., Willsher P., Wilcken N., Crombie C., Forbes J.F., Abell F., Ackland S., Bonaventura A., Cox S., Denham J., Gourlay R., Jackson D., Sillar R., Stewart J., Lewis C., Brigham B., Goldstein D., Friedlander M., Walpole E., Thompson D., Gill P.G., Bochner M., Coventry J., Kollias J., Malycha P., Olver I., Colosimo M., Cheuk R., Kenny L., McCarthy N., Wyld D., Young R., Harrup R., Kimber R., Lowenthal R., Trotter J., Bayliss E., Chan A., Ransom D., Byrne M., Buck M., Dewar J., Nowak A., Powell A., Van Hazel G., Abdi E.A., Brodribb R., Volobueva Z., Harnett P., Ahern V., Gurney H., Wilcken N., Harvey V.J., Evans B., Jones W., McCrystal M., Porter D., Thompson P., Vaughan M., Gibbs D., Atkinson C., Burcombe R., Fitzharris B., Hickey B., Jeffery M., Robinson B., McLaren B., Costello S., North J., Perez D., Campbell I.D., Gilbert L., Gannaway R., Jameson M., Kennedy I., Long J., Round G., Spellman L., Whittle D., Woolerton D., Menke C., Biazús J., Cericatto R., Cavalheiro J., Xavier N., Bittelbrunn A., Rabin E., Gutiérrez J., Arriagada R., Bronfman L., Zuñiga M., Gutiérrez J., Acevedo J.C., Torres S., León A., Salazar E., Diaz L.S., Duval R., Oddeshede N., Venti M.C., Peña K., Puente L., Maidana V., Baeza R., Arriagada R., Olfos P., Solé J., Vinés E., Mariani C., Láng I., Hitre E., Szabó E., Horváth Z., Ganofszky E., Juhos E., Veronesi A., Crivellari D., Magri M.D., Buonadonna A., Coran F., Borsatti E., Candiani E., Massarut S., Roncadin M., Arcicasa M., Carbone A., Perin T., Gloghini A., Tondini C., Labianca R., Poletti P., Bettini A., Clerico M., Vincenti M., Malossi A., Seles E., Perfetti E., Sartorello B., Simoncini E., Marini G., Marpicati P., Farfaglia R., Bianchi A.M., Grigolato P., Lucini L., Frata P., Huscher A., Micheletti E., Fogazzi C., Artioli F., Cagossi K., Scaltriti L., Bandieri E., Botticelli L., Giovanardi G., Ravaioli A., Pasquini E., Rudnas B., Foghin L., Visini M., Zavallone L., Ucci G., Colleoni M., Viale G., Veronesi P., Peruzzotti G., Corsetto L., Ghisini R., Renne G., Luini A., Orlando L., Torrisi R., Rocca A., De Pas T., Munzone E., Galimberti V., Zurrida S., Intra M., Nolé F., Orecchia R., Martinelli G., de Braud F., Goldhirsch A., Ravaioli A., Gianni L., Gome H., Cufer T., Pajk B., Cervek J., Werner I.D., Murray E., Govender D., Dalvie S., Erasmus T., Robertson B., Read B., Nel E., Toop J., Nedeva N., Panieri E., Vorobiof D., Chasen M., McMichael G., Mohammed C., Holmberg S.B., Holmberg S.B., Mattsson J., Sellström H., Lindberg B., Goldhirsch A., Herrmann R., Schönenberger A., Mingrone W., Honegger Ch, Bärtschi E., Neter M., Rederer M., Schär G., Rochlitz C., Herrmann R., Oertli D., Wight E., Moch H., Bernier J., Bronz L., Cavalli F., Gallerani E., Richetti A., Franzetti A., Conti-Beltraminelli M., Ghielmini M., Gyr T., Mauri S., Saletti P.C., Goldhirsch A., Pagani O., Graffeo R., Locatelli M., Longhi S., Rey P.C., Ruggeri M., Zucca E., Wyss D., Mazzucchelli L., Pedrinis E., Rusca T., Aebi S., Fey M.F., Castiglione M., Rabaglio M., Aebi S., Fey M.F., Zuber M., Beck G., Aebi S., Fey M.F., Schönenberger R., Lüthi J.M., Rauch D., Bonnefoi H., Egli F., Steiner R., Fehr P., Perey L., de Grandi P., Jeanneret W., Leyvraz S., Delaloye J.F., Thürlimann B., Köberle D., Weisser F., Mattmann S., Müller A., Cerny T., Späti B., Höfliger M., Fürstenberger G., Bolliger B., Öhlschlegel C., Lorenz U., Bamert M., Kehl-Blank J., Vogel E., Thürlimann B., Hess D., Senn I., Köberle D., Ehrsam A., Nauer C., Öhlschlegel C., Kehl-Blank J., Vogel E., Widmer L., Häfner M., Pestalozzi B.C., Fehr M., Caduff R., Varga Z., Trüb R., Fink D., Bättig B.A., Buser K., Bürki N., Dieterle A., Hasler L., Mannhart-Harms M., Rageth C., Richner J., Spataro V., Umbricht M., Ellis P., Harris S., Akbar N., McVicars H., Lees C., Raman R., Crane G.
ISSN
1465-542X (Electronic)
ISSN-L
1465-5411
Publication state
Published
Issued date
26/05/2011
Peer-reviewed
Oui
Volume
13
Number
3
Pages
209
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
Publication Status: epublish
Publication Status: epublish
Abstract
The Breast International Group (BIG) 1-98 study is a four-arm trial comparing 5 years of monotherapy with tamoxifen or with letrozole or with sequences of 2 years of one followed by 3 years of the other for postmenopausal women with endocrine-responsive early invasive breast cancer. From 1998 to 2003, BIG -98 enrolled 8,010 women. The enhanced design f the trial enabled two complementary analyses of efficacy and safety. Collection of tumor specimens further enabled treatment comparisons based on tumor biology. Reports of BIG 1-98 should be interpreted in relation to each individual patient as she weighs the costs and benefits of available treatments. Clinicaltrials.gov ID: NCT00004205.
Keywords
Breast Neoplasms/drug therapy, Chemotherapy, Adjuvant, Clinical Trials, Phase III as Topic, Double-Blind Method, Female, Humans, Letrozole, Nitriles/administration & dosage, Nitriles/adverse effects, Nitriles/therapeutic use, Randomized Controlled Trials as Topic, Receptor, ErbB-2/metabolism, Receptors, Estrogen/metabolism, Receptors, Progesterone/metabolism, Tamoxifen/administration & dosage, Tamoxifen/adverse effects, Tamoxifen/therapeutic use, Triazoles/administration & dosage, Triazoles/adverse effects, Triazoles/therapeutic use
Pubmed
Web of science
Open Access
Yes
Create date
07/02/2012 10:18
Last modification date
09/08/2024 15:52