Connexin37 in normal and pathological development of mouse heart and great arteries

Détails

ID Serval
serval:BIB_F241A3790471
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Connexin37 in normal and pathological development of mouse heart and great arteries
Périodique
Developmental Dynamics
Auteur(s)
Haefliger  J. A., Polikar  R., Schnyder  G., Burdet  M., Sutter  E., Pexieder  T., Nicod  P., Meda  P.
ISSN
1058-8388 (Print)
Statut éditorial
Publié
Date de publication
06/2000
Volume
218
Numéro
2
Pages
331-44
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S. --- Old month value: Jun
Résumé
Cx37 is a member of the connexin family of gap junction proteins, whose distribution in heart remains controversial. We have generated novel antibodies against Cx37 to investigate this distribution during normal and pathological development in mouse. Using these affinity-purified antibodies, we have detected Cx37 in hearts and aortas of mouse embryos from day 11 ed. onwards. Immunostaining revealed that during prenatal development Cx37 predominated in endothelial and endocardial cells but was also detectable in small amounts in the trabeculated and compact layers of ventricular myocardium, as well as in the mesenchyme of conotruncal ridges and atrioventricular cushions. Cx37 was also differentially expressed in the ascending and descending portions of the embryonic aorta, according to a pattern which differed in the three layers of the vessel wall. Cx37 distribution was altered in both heart and aorta of mice that had been exposed to all-trans retinoic acid at the beginning of foetal development, whether or not these animals subsequently developed a transposition of great arteries. The data indicate that Cx37 is widely distributed in multiple compartments of cardiovascular system, in patterns which are modulated during development, by retinoic acid.
Mots-clé
Animals Aorta/*metabolism/pathology Connexins/genetics/immunology/*metabolism Heart/drug effects/*embryology Mice Myocardium/*metabolism/pathology Rabbits Rats Tissue Distribution Tretinoin/pharmacology
Pubmed
Web of science
Création de la notice
25/01/2008 14:47
Dernière modification de la notice
03/03/2018 22:40
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