P8: Mucoepidermoid carcinoma of the palate presenting as an intraoral squamous papilloma. Description of a challenging case

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ID Serval
serval:BIB_F2012A4BE7DA
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Poster: résume de manière illustrée et sur une page unique les résultats d'un projet de recherche. Les résumés de poster doivent être entrés sous "Abstract" et non "Poster".
Collection
Publications
Titre
P8: Mucoepidermoid carcinoma of the palate presenting as an intraoral squamous papilloma. Description of a challenging case
Titre de la conférence
Swiss Pathology Days
Auteur(s)
Sarro R., Ziadi S., Gu C., Bongiovanni M., Bisig B., La Rosa S.
Adresse
Thun, Switzerland, November 10-12, 2017
ISSN
0172-8113
1432-1963
ISSN-L
1432-1963
Statut éditorial
Publié
Date de publication
20/10/2017
Volume
38
Numéro
6
Série
Der Pathologe
Pages
575-576
Langue
anglais
Résumé
Background: Mucoepidermoid carcinoma (MEC) is the most common malignant
salivary gland tumor, composed of mucinous, intermediate (clear)
and squamoid cells. The palate is the second most common site after the parotid
gland. Most MECs show recurrent translocations involving MAML2
gene and either CRTC1 (60–80%) or CRTC3 (<6%). In the palate, MEC generally
presents as a deeply infiltrative mass. We describe the morphological and FISH analyses of a palatal MEC presenting as an intraoral squamous
papilloma, which, as far as we know, has never previously been described.
Methods: We report a case of an otherwise healthy 55-year-old man who
complained of a painless oral lesion in the left hard palate since more than
20 years. Clinically, a papillomatous lesion was noticed and a superficial
biopsy was consistent with a squamous papilloma. CT scan showed a palatine
lytic mass and the patient underwent left maxillectomy.
Results: The initial biopsy, performed in an outside institution, was not
available for review. At gross analysis the resection specimen showed a
3.2 cm large left hard palate tumour infiltrating the maxillary bone (palatine
processus and maxillary sinus) and nasal submucosa through the palatine
bone, with a superficial papillomatous component. Histologically, the
hard palate mucosa showed a superficial papillomatous epithelial proliferation
overlying a low grade MEC. Break-apart FISH analysis (ZytoVision
probe) showed a MAML2 gene rearrangement in the two components of
the lesion: both in the deeply infiltrating typical MEC and in the superficial
papillomatous component.
Conclusions: The present case illustrates an uncommon feature of palatal
MEC. The presence of a superficial papilloma challenged the adequate classification
of this lesion at first diagnostic approach. FISH analysis finally
demonstrated a clonal relationship between the two observed components,
highlighting that MEC may present clinically as an intraoral papilloma.
Création de la notice
13/11/2017 15:16
Dernière modification de la notice
03/03/2018 22:39
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