Oral contraceptives and the risk of endometrial cancer

Details

Serval ID
serval:BIB_F1FC9BB48398
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Oral contraceptives and the risk of endometrial cancer
Journal
Cancer Causes and Control
Author(s)
Levi  F., La Vecchia  C., Gulie  C., Negri  E., Monnier  V., Franceschi  S., Delaloye  J. F., De Grandi  P.
ISSN
0957-5243 (Print)
Publication state
Published
Issued date
03/1991
Volume
2
Number
2
Pages
99-103
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar
Abstract
The relationship between the use of combination oral contraceptives (OCs) and the risk of endometrial cancer was assessed in a case-control study conducted in the Swiss Canton of Vaud between 1 January 1988 and 31 July 1990. Subjects included 122 women aged 75 or less with histologically confirmed endometrial cancer, and 309 control women in hospital for acute conditions unrelated to OC use. Overall, 14 percent of cases and 27 percent of controls had ever used OCs, corresponding to a multivariate relative risk (RR) of 0.5 (95 percent confidence interval [CI]: 0.3, 0.8). The risk of endometrial cancer was found to be related inversely to duration of OC use: RR = 1.0 for less than two years of OC use; 0.5 for two to five years; and 0.3 (95 percent CI: 0.1, 0.7) for more than five years. The protection appeared greater within 20 years since last use, and the RR rose to 0.8 after 20 or more years since last use; numbers are too small, however, for reliable inference from these subanalyses. No significant interaction or modifying effect was observed with other major factors related to endometrial cancer, including parity, body mass index, estrogen replacement therapy, and cigarette smoking. While this study provides further evidence for the protective effect of OCs against risk of endometrial cancer, the relationship requires continued evaluation to assess the long-term implications and public health impact of OC use.
Keywords
Age Factors Aged Body Mass Index Case-Control Studies Contraceptives, Oral/*adverse effects Female Humans Middle Aged Risk Factors Smoking/adverse effects Time Factors Uterine Neoplasms/*chemically induced
Pubmed
Web of science
Create date
25/01/2008 15:43
Last modification date
20/08/2019 16:19
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