Expert Opinion on Three Phage Therapy Related Topics: Bacterial Phage Resistance, Phage Training and Prophages in Bacterial Production Strains.

Détails

Ressource 1Télécharger: viruses-10-00178.pdf (286.35 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_F1F98CD58878
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Expert Opinion on Three Phage Therapy Related Topics: Bacterial Phage Resistance, Phage Training and Prophages in Bacterial Production Strains.
Périodique
Viruses
Auteur(s)
Rohde C., Resch G., Pirnay J.P., Blasdel B.G., Debarbieux L., Gelman D., Górski A., Hazan R., Huys I., Kakabadze E., Łobocka M., Maestri A., Almeida GMF, Makalatia K., Malik D.J., Mašlaňová I., Merabishvili M., Pantucek R., Rose T., Štveráková D., Van Raemdonck H., Verbeken G., Chanishvili N.
ISSN
1999-4915 (Electronic)
ISSN-L
1999-4915
Statut éditorial
Publié
Date de publication
2018
Peer-reviewed
Oui
Volume
10
Numéro
4
Pages
1-15
Langue
anglais
Résumé
Phage therapy is increasingly put forward as a "new" potential tool in the fight against antibiotic resistant infections. During the "Centennial Celebration of Bacteriophage Research" conference in Tbilisi, Georgia on 26-29 June 2017, an international group of phage researchers committed to elaborate an expert opinion on three contentious phage therapy related issues that are hampering clinical progress in the field of phage therapy. This paper explores and discusses bacterial phage resistance, phage training and the presence of prophages in bacterial production strains while reviewing relevant research findings and experiences. Our purpose is to inform phage therapy stakeholders such as policy makers, officials of the competent authorities for medicines, phage researchers and phage producers, and members of the pharmaceutical industry. This brief also points out potential avenues for future phage therapy research and development as it specifically addresses those overarching questions that currently call for attention whenever phages go into purification processes for application.
Mots-clé
Bacteriophage, adaptation, phage therapy, production, prophage, regulation, resistance
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/04/2018 11:23
Dernière modification de la notice
09/05/2019 3:20
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