Thermogenesis induced by five different intravenous glucose/insulin infusions in healthy young men.

Details

Serval ID
serval:BIB_F1DA3CB03419
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Thermogenesis induced by five different intravenous glucose/insulin infusions in healthy young men.
Journal
Clinical Nutrition
Author(s)
Schutz Y., Thiébaud D., Acheson K.J., Felber J.P., Defronzo R.A., Jéquier E.
ISSN
0261-5614 (Print)
ISSN-L
0261-5614
Publication state
Published
Issued date
1983
Volume
2
Number
2
Pages
93-96
Language
english
Abstract
The thermogenic response induced by glucose/insulin administered intravenously was examined in 22 healthy male volunteers using indirect calorimetry in combination with the euglycaemic insulin clamp technique. Five increasing steady state levels of insulinaemia (62 muU/ml to 1132 muU/ml) were achieved by means of continuous infusions of insulin at 5 rates ranging from 0.5 mU/kg.min to 10 mU/kg.min. Euglycaemia was maintained at each insulin level by infusing glucose at different rates ranging from steady state values of 0.41 g/min to 0.77 g/min. These glucose/insulin infusions resulted in a significant net rise in resting energy expenditure from 0.33 kJ/min to 0.94 kJ/min over preinfusion baseline values for the lowest and the highest doses respectively. There was a highly significant relationship (r = 0.93, p<0.001, n = 42) between the amount of glucose infused and the net increase in energy expenditure over preinfusion baseline values. Intravenous glucose induced thermogenesis (GIT(iv)) was calculated as incremental values of energy expenditure related to step changes in glucose infusion rates. GIT(iv) was found to be approximately 5.5% a physiological plasma insulin levels (i.e. below 200 muU/ml) whereas at supraphysiological levels (i.e.>400 muU/ml) GIT(iv) was increased up to 8%. It was concluded that: 1. the magnitude of the GIT(iv) at physiological insulinaemia was similar to that found by other investigators who have administered glucose per os; 2. the elevated thermogenesis observed at high doses of glucose/insulin infusion is consistent with recent clinical findings showing a markedly increased energy expenditure in patients supported by large quantities of intravenous glucose (TPN).
Pubmed
Create date
21/01/2008 13:08
Last modification date
20/08/2019 16:19
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