Surveillance of HIV type 1 drug resistance among naive patients from Venezuela.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_F1CE32A29002
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Surveillance of HIV type 1 drug resistance among naive patients from Venezuela.
Périodique
AIDS Research and Human Retroviruses
Auteur(s)
Castillo J., Comegna M., Quijada W., Jauvin V., Pinson P., Masquelier B., Fleury H., Castro E.
ISSN
1931-8405 ([electronic])
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
25
Numéro
12
Pages
1329-1333
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
We have studied 65 HIV-1-infected untreated patients recruited in Caracas, Venezuela with TCD4 counts > or =350/microl. The reverse transcriptase and protease sequences of the virus were sequenced, aligned with reference HIV-1 group M strains, and analyzed for drug resistance mutations. Most of the viruses were subtype B genotype in both the protease and RT genomic regions. Five of the 62 virus isolates successfully amplified showed evidence of recombination between protease and RT, with their protease region being non-B while their RT region was derived from subtype B. Four strains were found bearing resistance mutations either to NRTIs, NNRTIs, or PIs. The prevalence of HIV-1 isolates bearing resistance mutations was therefore above the 5% threshold of WHO.
Pubmed
Web of science
Open Access
Oui
Création de la notice
26/01/2010 16:42
Dernière modification de la notice
20/08/2019 17:19
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