Successful migration of three tracers without identification of sentinel nodes during intraoperative lymphatic mapping for non-small cell lung cancer.

Détails

ID Serval
serval:BIB_F1BAF39AA179
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Successful migration of three tracers without identification of sentinel nodes during intraoperative lymphatic mapping for non-small cell lung cancer.
Périodique
Interactive Cardiovascular and Thoracic Surgery
Auteur(s)
Meyer A., Cheng C., Antonescu C., Pezzetta E., Bischof-Delaloye A., Ris H.B.
ISSN
1569-9285[electronic]
Statut éditorial
Publié
Date de publication
2007
Volume
6
Numéro
2
Pages
214-218
Langue
anglais
Notes
Publication types: Comparative Study ; Evaluation Studies ; Journal Article - Publication Status: ppublish
Résumé
Prospective comparative evaluation of patent V blue, fluorescein and (99m)TC-nanocolloids for intraoperative sentinel lymph node (SLN) mapping during surgery for non-small cell lung cancer (NSCLC). Ten patients with peripherally localised clinical stage I NSCLC underwent thoracotomy and peritumoral subpleural injection of 2 ml of patent V blue dye, 1 ml of 10% fluorescein and 1ml of (99m)Tc-nanocolloids (0.4 mCi). The migration and spatial distribution pattern of the tracers was assessed by direct visualisation (patent V blue), visualisation of fluorescence signalling by a lamp of Wood (fluorescein) and radioactivity counting with a hand held gamma-probe ((99m)Tc-nanocolloids). Lymph nodes at interlobar (ATS 11), hilar (ATS 10) and mediastinal (right ATS 2,4,7; left ATS 5,6,7) levels were systematically assessed every 10 min up to 60 min after injection, followed by lobectomy and formal lymph node dissection. Successful migration from the peritumoral area to the mediastinum was observed for all three tracers up to 60 min after injection. The interlobar lympho-fatty tissue (station ATS 11) revealed an early and preferential accumulation of all three tracers for all tumours assessed and irrespective of the tumour localisation. However, no preferential accumulation in one or two distinct lymph nodes was observed up to 60 min after injection for all three tracers assessed. Intraoperative SLN mapping revealed successful migration of the tracers from the site of peritumoral injection to the mediastinum, but in a diffuse pattern without preferential accumulation in sentinel lymph nodes.
Mots-clé
Aged, Carcinoma, Non-Small-Cell Lung, Feasibility Studies, Female, Fluorescein, Fluorescent Dyes, Humans, Injections, Intralesional, Intraoperative Care, Lung Neoplasms, Lymph Nodes, Lymphatic Metastasis, Male, Middle Aged, Neoplasm Staging, Patient Selection, Pneumonectomy, Prospective Studies, Radiopharmaceuticals, Rosaniline Dyes, Sentinel Lymph Node Biopsy, Technetium Tc 99m Aggregated Albumin, Time Factors, Treatment Outcome
Pubmed
Création de la notice
29/01/2008 14:00
Dernière modification de la notice
03/03/2018 22:39
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