Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Proteine mit Einfluss auf die Blutgerinnung [Proteins influencing the blood coagulation].
Therapeutische Umschau. Revue Thérapeutique
Publication types: English Abstract ; Journal Article ; Review Publication Status: ppublish
This review describes some natural proteins, which can be employed, either as factor concentrates derived from human plasma or as recombinant drug, to modulate the coagulation system. I will address some biochemical characteristics and the physiological role of von Willebrand factor, the coagulation factors of the extrinsic and intrinsic pathways, and the physiological anticoagulant protein C. In addition, I will detail the pharmacological compounds, which are available for influencing or substituting the coagulation proteins: desmopressin (DDAVP), single coagulation factor concentrates, prothrombin complex concentrates, and protein C concentrate. In particular, I will address some treatment topics of general medical interest, such as the treatment of massive bleeding, the correction of the coagulopathy induced by vitamin K-antagonists in patients with cerebral haemorrhage, and of the coagulopathy of meningococcemia. Finally, I will describe some properties and practical clinical applications of the recombinant anticoagulans lepirudin and bivalirudin, which are derived from hirudin, the natural anticoagulant of the medical leech.
Anticoagulants/adverse effects, Anticoagulants/therapeutic use, Blood Coagulation Disorders/blood, Blood Coagulation Disorders/drug therapy, Blood Coagulation Factors/adverse effects, Blood Coagulation Factors/therapeutic use, Blood Proteins/adverse effects, Blood Proteins/therapeutic use, Cerebral Hemorrhage/blood, Cerebral Hemorrhage/chemically induced, Hemorrhage/blood, Hemorrhage/drug therapy, Hirudins/adverse effects, Humans, Peptide Fragments/adverse effects, Peptide Fragments/therapeutic use, Protein C/adverse effects, Protein C/therapeutic use, Recombinant Proteins/adverse effects, Recombinant Proteins/therapeutic use, Vitamin K/antagonists & inhibitors, von Willebrand Factor/adverse effects, von Willebrand Factor/therapeutic use
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