T cell regeneration in HIV-infected subjects under highly active antiretroviral therapy (review)

Détails

ID Serval
serval:BIB_F1B50FB6E67E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
T cell regeneration in HIV-infected subjects under highly active antiretroviral therapy (review)
Périodique
International Journal of Molecular Medicine
Auteur(s)
Fleury  S., Pantaleo  G.
ISSN
1107-3756 (Print)
Statut éditorial
Publié
Date de publication
07/1999
Volume
4
Numéro
1
Pages
91-7
Notes
Journal Article
Review --- Old month value: Jul
Résumé
The initial idea that high amounts of cytopathic virus produced everyday can drive high CD4+ T cell production seemed logical and explained the progressive CD4+ T cell depletion observed in HIV-infected subjects. It was hypothesized that the CD4+ T lymphocyte production was increased up to 70-fold in HIV-infected subjects. Determination of the CD4+ T cell production was based on the kinetics of CD4+ T cell recovery following initiation of highly active antiretroviral therapy (HAART). However, this analysis is limited by: i) the assumption that blood CD4+ T cells are representative of the lymph node T cells; and ii) the lack of estimates of CD4+ T lymphocyte turnover in healthy HIV-negative subjects. Several immunologists have expressed caution regarding the assumptions used in modeling CD4+ T cell dynamics. Recent findings clearly show that blood is not representative of lymphoid tissues and invalidate the conclusion of high CD4 turnover drawn from blood studies on HIV-infected subjects. Indeed, when blood and lymph node compartments are considered together, we find that HIV-infected subjects naive to antiretroviral have similar or lower CD4+ T cell production, as compared to healthy subjects. This observation suggests an impaired T cell renewal capacity in HIV-1 infected patients.
Mots-clé
Anti-HIV Agents/*therapeutic use CD4 Lymphocyte Count CD4-Positive T-Lymphocytes/*drug effects/*immunology/pathology Cell Division HIV Infections/*drug therapy/*immunology/pathology Homeostasis Humans Immunologic Memory Lymphocyte Activation Models, Biological
Pubmed
Web of science
Création de la notice
25/01/2008 16:13
Dernière modification de la notice
03/03/2018 22:39
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