Sensing of invading pathogens by GBPs: At the crossroads between cell-autonomous and innate immunity.

Détails

ID Serval
serval:BIB_F183C2E25CDD
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Sensing of invading pathogens by GBPs: At the crossroads between cell-autonomous and innate immunity.
Périodique
Journal of leukocyte biology
Auteur(s)
Santos J.C., Broz P.
ISSN
1938-3673 (Electronic)
ISSN-L
0741-5400
Statut éditorial
Publié
Date de publication
10/2018
Peer-reviewed
Oui
Volume
104
Numéro
4
Pages
729-735
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Guanylate-binding proteins (GBPs) are conserved family of IFN-inducible GTPases that play an important role in the host immunity against bacterial, viral, and protozoan pathogens. GBPs protect the host by associating with intracellular microbes, their vacuolar niche or, in the case of viruses, with their replication complex. This association results in a restriction of the respective pathogen, yet the exact molecular mechanisms of the antimicrobial functions of GBPs are still unclear. Recent work has linked the GBPs with the activation of inflammasomes, multi-protein complexes that assemble upon recognition of pathogen- or host-derived signals and that drive the release of cytokines and host cell death. Here, we will focus on the most recent findings that have started to unravel the manifold restriction mechanism controlled by GBPs in mouse and human cells, and that shed light on the molecular cues that control GBP recruitment to bacterial membranes.
Mots-clé
Animals, Bacterial Infections/enzymology, Bacterial Infections/immunology, Caspases/physiology, Cell Membrane/metabolism, Cytokines/metabolism, GTP-Binding Proteins/physiology, Humans, Immunity, Innate, Infection/enzymology, Infection/immunology, Inflammasomes/immunology, Lipopolysaccharides/metabolism, Mammals/immunology, Mice, Parasitic Diseases/enzymology, Parasitic Diseases/immunology, Protein Transport, Protozoan Infections/enzymology, Protozoan Infections/immunology, Virus Diseases/enzymology, Virus Diseases/immunology, Guanylate-binding proteins, caspase-11, inflammasomes, intracellular pathogens
Pubmed
Web of science
Création de la notice
06/08/2018 17:08
Dernière modification de la notice
20/08/2019 17:19
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