Expression of the monocarboxylate transporter MCT1 in the adult human brain cortex.

Détails

ID Serval
serval:BIB_F17C9ACD8257
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Expression of the monocarboxylate transporter MCT1 in the adult human brain cortex.
Périodique
Brain Research
Auteur(s)
Chiry O., Pellerin L., Monnet-Tschudi F., Fishbein W.N., Merezhinskaya N., Magistretti P.J., Clarke S.
ISSN
0006-8993[print], 0006-8993[linking]
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
1070
Numéro
1
Pages
65-70
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Distribution of the monocarboxylate transporter MCT1 has been investigated in the cortex of normal adult human brain. Similarly to the glucose transporter GLUT1 55 kDa isoform, MCT1 was found to be strongly expressed on blood vessels in all cortical layers. In addition, laminar analysis revealed intense MCT1 expression in the neuropil of layer IV in primary auditory (AI) and visual (VI) areas, while this expression was more homogeneous in the non-primary auditory area STA. The cellular distribution shows that MCT1 is strongly expressed by glial cells often associated with blood vessels that were identified as astrocytes. The observed distribution of MCT1 supports the concept that, under certain circumstances, monocarboxylates could be provided as energy substrates to the adult human brain. Moreover, the distinct laminar pattern of MCT1 expression between primary and non-primary cortical areas may reflect different types of neuronal activity requiring adequate supply of specific energy substrates.
Mots-clé
Aged, Aged, 80 and over, Astrocytes/metabolism, Auditory Cortex/metabolism, Blood Vessels/metabolism, Cadaver, Cerebral Cortex/blood supply, Cerebral Cortex/cytology, Female, Humans, Male, Monocarboxylic Acid Transporters/metabolism, Neuropil/metabolism, Symporters/metabolism, Tissue Distribution, Visual Cortex/metabolism
Pubmed
Web of science
Création de la notice
05/02/2008 14:38
Dernière modification de la notice
03/03/2018 22:38
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