Association between anti-apolipoprotein A-1 antibodies and cardiovascular disease in the general population. Results from the CoLaus study.

Détails

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Etat: Serval
Version: Author's accepted manuscript
ID Serval
serval:BIB_F1631DFC66DD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Association between anti-apolipoprotein A-1 antibodies and cardiovascular disease in the general population. Results from the CoLaus study.
Périodique
Thrombosis and haemostasis
Auteur(s)
Antiochos P., Marques-Vidal P., Virzi J., Pagano S., Satta N., Bastardot F., Hartley O., Montecucco F., Mach F., Waeber G., Vollenweider P., Vuilleumier N.
ISSN
2567-689X (Electronic)
ISSN-L
0340-6245
Statut éditorial
Publié
Date de publication
27/09/2016
Peer-reviewed
Oui
Volume
116
Numéro
4
Pages
764-771
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
We aimed to determine the association between autoantibodies against apolipoprotein A-1 (anti-apoA-1 IgG) and prevalent cardiovascular (CV) disease (CVD) as well as markers of CV risk in the general population. Cross-sectional data were obtained from 6649 subjects (age 52.6 ± 10.7 years, 47.4 % male) of the population-based CoLaus study. CVD was defined as myocardial infarction, angina pectoris, percutaneous revascularisation or bypass grafting for ischaemic heart disease stroke or transient ischaemic attack, and was assessed according to standardised medical records. Anti-apoA-1 IgG and biological markers were measured by ELISA and conventional automated techniques, respectively. Prevalence of high anti-apoA-1 IgG levels in the general population was 19.9 %. Presence of anti-apoA-1 IgG was significantly associated with CVD [odds ratio 1.34, 95 % confidence interval (1.05-1.70), p=0.018], independently of established CV risk factors (CVRFs) including age, sex, hypertension, smoking, diabetes, low and high-density lipoprotein cholesterol levels. The n=455 (6.8 %) study participants with a history of CVD (secondary prevention subgroup) presented higher median anti-ApoA-1 IgG values compared with subjects without CVD (p=0.029). Among patients in the secondary prevention subgroup, those with positive anti-apoA-1 IgG levels had lower HDL (p=0.002) and magnesium (p=0.001) levels, but increased uric acid and high-sensitivity C-reactive protein levels (p=0.022, and p<0.001, respectively) compared to patients with negative anti-apoA-1 IgG levels. In conclusion, anti-apoA-1 IgG levels are independently associated with CVD in the general population and also related to CV biomarkers in secondary prevention. These findings indicate that anti-apoA-1 IgG may represent a novel CVRF and need further study in prospective cohorts.

Mots-clé
Adult, Apolipoprotein A-I/immunology, Autoantibodies/blood, Cardiovascular Diseases/blood, Cardiovascular Diseases/immunology, Cross-Sectional Studies, Female, Humans, Immunoglobulin G/blood, Male, Middle Aged, Anti-apolipoprotein A-1 antibodies, biomarker, cardiovascular disease, high-density lipoprotein cholesterol, population-based
Pubmed
Web of science
Création de la notice
03/11/2016 16:48
Dernière modification de la notice
12/04/2018 19:28
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