Cytoskeletal and DNA structure abnormalities result from bypass of requirement for the cdc10 start gene in the fission yeast Schizosaccharomyces pombe.

Details

Serval ID
serval:BIB_F14C05EBC07A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cytoskeletal and DNA structure abnormalities result from bypass of requirement for the cdc10 start gene in the fission yeast Schizosaccharomyces pombe.
Journal
Journal of Cell Science
Author(s)
Marks J., Fankhauser C., Reymond A., Simanis V.
ISSN
0021-9533 (Print)
ISSN-L
0021-9533
Publication state
Published
Issued date
1992
Volume
101
Number
3
Pages
517-528
Language
english
Abstract
The cdc10 gene of the fission yeast S. pombe is required for traverse of the start control in late G1 and commitment to the mitotic cell cycle. To increase our understanding of the events which occur at start, a pseudoreversion analysis was undertaken to identify genes whose products may interact with cdc10 or bypass the requirement for it. A single gene, sct1+ (suppressor of cdc ten), has been identified, mutation of which suppresses all conditional alleles and a null allele of cdc10. Bypass of the requirement for cdc10+ function by sct1-1 mutations leads to pleiotropic defects, including microtubule, microfilament and nuclear structural abnormalities. Our data suggest that sct1 encodes a protein that is dependent upon cdc10+ either for its normal function or expression, or is a component of a checkpoint that monitors execution of p85cdc10 function.
Keywords
Alleles, Caffeine/pharmacology, Cell Cycle/genetics, Cytoskeleton/ultrastructure, DNA, Fungal/ultrastructure, Flow Cytometry, Fungal Proteins/genetics, Gene Expression Regulation, Fungal, Genes, Fungal, Phenotype, Restriction Mapping, Schizosaccharomyces/genetics, Schizosaccharomyces/ultrastructure, Suppression, Genetic
Pubmed
Web of science
Create date
24/01/2008 15:52
Last modification date
20/08/2019 16:18
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