Cytoskeletal and DNA structure abnormalities result from bypass of requirement for the cdc10 start gene in the fission yeast Schizosaccharomyces pombe.

Détails

ID Serval
serval:BIB_F14C05EBC07A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Cytoskeletal and DNA structure abnormalities result from bypass of requirement for the cdc10 start gene in the fission yeast Schizosaccharomyces pombe.
Périodique
Journal of Cell Science
Auteur(s)
Marks J., Fankhauser C., Reymond A., Simanis V.
ISSN
0021-9533 (Print)
ISSN-L
0021-9533
Statut éditorial
Publié
Date de publication
1992
Volume
101
Numéro
3
Pages
517-528
Langue
anglais
Résumé
The cdc10 gene of the fission yeast S. pombe is required for traverse of the start control in late G1 and commitment to the mitotic cell cycle. To increase our understanding of the events which occur at start, a pseudoreversion analysis was undertaken to identify genes whose products may interact with cdc10 or bypass the requirement for it. A single gene, sct1+ (suppressor of cdc ten), has been identified, mutation of which suppresses all conditional alleles and a null allele of cdc10. Bypass of the requirement for cdc10+ function by sct1-1 mutations leads to pleiotropic defects, including microtubule, microfilament and nuclear structural abnormalities. Our data suggest that sct1 encodes a protein that is dependent upon cdc10+ either for its normal function or expression, or is a component of a checkpoint that monitors execution of p85cdc10 function.
Mots-clé
Alleles, Caffeine/pharmacology, Cell Cycle/genetics, Cytoskeleton/ultrastructure, DNA, Fungal/ultrastructure, Flow Cytometry, Fungal Proteins/genetics, Gene Expression Regulation, Fungal, Genes, Fungal, Phenotype, Restriction Mapping, Schizosaccharomyces/genetics, Schizosaccharomyces/ultrastructure, Suppression, Genetic
Pubmed
Web of science
Création de la notice
24/01/2008 16:52
Dernière modification de la notice
03/03/2018 22:38
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