Effect of repetitive arm cycling following botulinum toxin injection for poststroke spasticity: evidence from FMRI.

Détails

ID Serval
serval:BIB_F13636F5A68C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Effect of repetitive arm cycling following botulinum toxin injection for poststroke spasticity: evidence from FMRI.
Périodique
Neurorehabilitation and Neural Repair
Auteur(s)
Diserens K., Ruegg D., Kleiser R., Hyde S., Perret N., Vuadens P., Fornari E., Vingerhoets F., Seitz R.J.
ISSN
1545-9683
1552-6844 (Electronic)
ISSN-L
1545-9683
Statut éditorial
Publié
Date de publication
2010
Volume
24
Numéro
8
Pages
753-762
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
BACKGROUND AND OBJECTIVE: Investigations were performed to establish if repetitive arm cycling training enhances the antispastic effect of intramuscular botulinum toxin (BTX) injections in postischemic spastic hemiparesis. Effects on cerebral activation were evaluated by functional magnetic resonance imaging (fMRI).
METHODS: Eight chronic spastic hemisyndrome patients (49 ± 10 years) after middle cerebral artery infarction (5.5 ± 2.7 years) were investigated. BTX was injected into the affected arm twice, 6 months apart. Spasticity was assessed using the Ashworth Scale and range of motion before and 3 months after BTX injections. Images were analyzed using Brain Voyager QX 1.8, and fMRI signal changes were corrected for multiple comparisons.
RESULTS: During passive movements of affected and nonaffected hands, fMRI activity was increased bilaterally in the sensorimotor cortex (MISI), secondary somatosensory areas (SII), and supplementary motor area predominantly in the contralesional hemisphere, compared with the rest. Following repetitive arm cycling, fMRI activity increased further in MISI of the lesioned hemisphere and SII of the contralesional hemisphere. For patients with residual motor activity, treatment-related fMRI activity increases were associated with reduced spasticity; in completely plegic patients, there was no fMRI activity change in SII but increased spasticity after training.
CONCLUSION: Increased activity in SII of the contralesional hemisphere and in MISI of the lesioned hemisphere reflect a treatment-induced effect in the paretic arm. It is hypothesized that the increased BOLD activity results from increased afferent information related to the antispastic BTX effect reinforced by training.
Mots-clé
Adult, Anti-Dyskinesia Agents/administration & dosage, Arm/physiopathology, Botulinum Toxins/administration & dosage, Cerebral Cortex/physiopathology, Female, Follow-Up Studies, Functional Laterality, Hand, Hemiplegia/drug therapy, Hemiplegia/etiology, Humans, Infarction, Middle Cerebral Artery/complications, Infarction, Middle Cerebral Artery/physiopathology, Injections, Intramuscular, Magnetic Resonance Imaging, Male, Middle Aged, Motor Activity, Motor Cortex/physiopathology, Movement/drug effects, Muscle Spasticity/drug therapy, Muscle Spasticity/physiopathology, Physical Therapy Modalities, Range of Motion, Articular/drug effects, Recovery of Function, Time Factors, Treatment Outcome
Pubmed
Web of science
Création de la notice
27/10/2010 13:24
Dernière modification de la notice
20/08/2019 17:18
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