Ketoacidosis and adrenocortical insufficiency.

Détails

ID Serval
serval:BIB_F128C234E676
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Ketoacidosis and adrenocortical insufficiency.
Périodique
Journal of Forensic Sciences
Auteur(s)
Palmiere C., de Froidmont S., Mangin P., Werner D., Lobrinus J.A.
ISSN
1556-4029 (Electronic)
ISSN-L
0022-1198
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
59
Numéro
4
Pages
1146-1152
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish PDF : Case report
Résumé
We herein report an autopsy case involving a 27-year-old Caucasian woman suffering from chronic adrenocortical insufficiency with a background of a polyendocrine disorder. Postmortem biochemistry revealed pathologically decreased aldosterone, cortisol, and dehydroepiandrosterone levels in postmortem serum from femoral blood as well as decreased cortisol and 17-hydroxycorticosteroid in urine. Decreased vitreous sodium and increased 3-beta-hydroxybutyrate and C-reactive protein concentrations were observed. The cause of death was determined to be acute adrenocortical insufficiency. Fasting ketoacidosis was postulated to have precipitated the Addisonian crisis. Traumatic causes of death and third-party involvement were excluded. The case highlights the importance of systematically performing exhaustive postmortem biochemical investigations to formulate appropriate hypothesis regarding the pathophysiological mechanisms involved in the death process.
Mots-clé
Addisonian crisis, adrenocortical insufficiency, fasting, forensic sciences, ketoacidosis, postmortem biochemistry
Pubmed
Web of science
Création de la notice
27/07/2014 16:13
Dernière modification de la notice
03/03/2018 22:38
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